Protein Variants | Comment | Organism |
---|---|---|
additional information | mutations in the HTRA1 gene cause a hereditary cerebral small-vessel disease, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy | Homo sapiens |
S328A | the mutation abolishes protease activity in HTRA1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | HTRA1 fails to cleave mature transforming growth factor-beta1 | Homo sapiens | ? | - |
? | |
pro-transforming growth factor-beta1 + H2O | - |
Homo sapiens | mature transforming growth factor-beta1 + latency-associated peptide | latency-associated peptide is the N-terminal of pro-transforming growth factor-beta1 | ? |
Synonyms | Comment | Organism |
---|---|---|
high-temperature requirement A1 protease | - |
Homo sapiens |
HtrA1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy-associated mutant HTRA1 decreases protease activity and fails to decrease transforming growth factor-beta family signaling | Homo sapiens |
physiological function | HTRA1 decreases transforming growth factor-beta1 signaling triggered by pro-transforming growth factor-beta1 in the intracellular space | Homo sapiens |