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Literature summary for 3.4.21.107 extracted from

  • Beleford, D.; Liu, Z.; Rattan, R.; Quagliuolo, L.; Boccellino, M.; Baldi, A.; Maguire, J.; Staub, J.; Molina, J.; Shridhar, V.
    Methylation induced gene silencing of HtrA3 in smoking-related lung cancer (2010), Clin. Cancer Res., 16, 398-409.
    View publication on PubMed
Search for more literature for 3.4.21.107

Application

Application Comment Organism
medicine cigarette smoke–induced methylation of HtrA3 can contribute to the etiology of chemoresistant disease in smoking-related lung cancer Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 x * 42000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEAS-2B cell
-
 Homo sapiens
-
EKVX cell
-
 Homo sapiens
-
H-650 cell
-
 Homo sapiens
-
H-69AR cell
-
 Homo sapiens
-
H-82 cell
-
 Homo sapiens
-
HCC-2935 cell
-
 Homo sapiens
-
HCC-4006 cell
-
 Homo sapiens
-
HCC-827 cell
-
 Homo sapiens
-
HOP-62 cell
-
 Homo sapiens
-
lung cancer cell primary cell Homo sapiens
-
NCI-H526 cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 42000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
HtrA3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HtrA3 expression is reduced or completely lost in over 50% of lung cancer cell lines and primary lung tumors from heavy smokers. An increased frequency of methylation within the first exon of HtrA3 corresponds to a loss of HtrA3 expression, particularly in tumors from smokers. 4-(methylnitrosamino)-I-(3-pyridyl)-1-butanone results in HtrA3 downregulation with a corresponding increase in methylation. HtrA3 expression is reduced after 15 days of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone treatment (0.01 mM) down
Homo sapiens treatment of HtrA3-deficient cell lines with 5-aza-2’-deoxycytidine results in a dose-dependent increase in HtrA3 transcription. HtrA3 expression is induced by the histone deacetylase inhibitor LBH589 up