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Literature summary for 3.4.21.107 extracted from
- Role of DegP for two-partner secretion in Bordetella (2009), Mol. Microbiol., 74, 315-329.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Bordetella pertussis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S237A | protease-inactive mutant | Bordetella pertussis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| periplasm | - |
Bordetella pertussis | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| filamentous haemagglutinin precursor + H2O | Bordetella pertussis | DegP contributes to degrading the filamentous haemagglutinin precursor when it is blocked intracellularly | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bordetella pertussis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| casein + H2O | - |
Bordetella pertussis | ? | - |
? | |
| filamentous haemagglutinin precursor + H2O | DegP contributes to degrading the filamentous haemagglutinin precursor when it is blocked intracellularly | Bordetella pertussis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DegP | - |
Bordetella pertussis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | Bordetella pertussis lacking the periplasmic chaperone/protease DegP has a strong growth defect at 37°C, and the integrity of its outer membrane is compromised | Bordetella pertussis |
| physiological function | DegP is critical for growth and for membrane integrity of Bordetella pertussis at 37°C. The chaperone activity of DegP markedly alleviates the periplasmic stress, DegP chaperones the extended filamentous haemagglutinin polypeptide in the periplasm and is thus involved in the two-partner secretion pathway | Bordetella pertussis |
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