Literature summary for 3.4.21.107 extracted from

Belanger, K.D.; Walter, D.; Henderson, T.A.; Yelton, A.L.; OBrien, T.G.; Belanger, K.G.; Geier, S.J.; Fahrenkrog, B.
Nuclear localisation is crucial for the proapoptotic activity of the HtrA-like serine protease Nma111p (2009), J. Cell Sci., 122, 3931-3941.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	Nma111p does not shuttle between the nucleus and cytoplasm	Saccharomyces cerevisiae	5634	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Synonyms

Synonyms	Comment	Organism
Nma111p	contains an HtrA-like serine-protease domain	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
malfunction	lack of nuclear localisation of Nma111p causes late onset of cell death during chronological ageing	Saccharomyces cerevisiae
physiological function	Nma111p functions as a nuclear serine protease that is necessary for apoptosis under cellular stress conditions, such as elevated temperature or treatment of cells with hydrogen peroxide to induce cell death. The nuclear localisation of Nma111p is required for its function in response to oxidative stress	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)