Application | Comment | Organism |
---|---|---|
medicine | HTRA1 is involved in osteoarthritis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a genetic variation (-625G>A, rs11200638) at the HTRA1 gene promoter locus is associated with spinal disc degeneration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | primary chondrocyte | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
high-temperature requirement A1 | - |
Homo sapiens |
HtrA1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | HTRA1 expression is upregulated in osteoarthritic joints, HTRA1 mRNA is increased by transforming growth factor-beta treatment (1 ng/ml for 24 h) in human primary chondrocytes | up |