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Literature summary for 3.4.21.107 extracted from

  • Urano, T.; Narusawa, K.; Kobayashi, S.; Shiraki, M.; Horie-Inoue, K.; Sasaki, N.; Hosoi, T.; Ouchi, Y.; Nakamura, T.; Inoue, S.
    Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women (2010), J. Bone Miner. Metab., 28, 220-226.
    View publication on PubMed

Application

Application Comment Organism
medicine HTRA1 is involved in osteoarthritis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a genetic variation (-625G>A, rs11200638) at the HTRA1 gene promoter locus is associated with spinal disc degeneration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte primary chondrocyte Homo sapiens
-

Synonyms

Synonyms Comment Organism
high-temperature requirement A1
-
Homo sapiens
HtrA1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HTRA1 expression is upregulated in osteoarthritic joints, HTRA1 mRNA is increased by transforming growth factor-beta treatment (1 ng/ml for 24 h) in human primary chondrocytes up