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Literature summary for 3.4.21.107 extracted from

  • An, E.; Sen, S.; Park, S.K.; Gordish-Dressman, H.; Hathout, Y.
    Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome (2010), Invest. Ophthalmol. Vis. Sci., 51, 3379-3386.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADAM9 + H2O Homo sapiens 54% cleavage ?
-
 ?
alpha2-macroglobulin + H2O Homo sapiens 55% cleavage ?
-
 ?
chloride intracellular channel protein 1 + H2O Homo sapiens 51% cleavage ?
-
 ?
clusterin + H2O Homo sapiens 50% cleavage ?
-
 ?
fascin + H2O Homo sapiens 40% cleavage ?
-
 ?
fibromodulin + H2O Homo sapiens 90% cleavage ?
-
 ?
additional information Homo sapiens HTRA1 does not cleave CFH protein, complement component C3 and complement component C3b ?
-
 ?
talin-1 + H2O Homo sapiens 21% cleavage ?
-
 ?
Vitronectin + H2O Homo sapiens 54% cleavage ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retinal pigment epithelium
-
 Homo sapiens
-
secretion
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADAM9 + H2O 54% cleavage Homo sapiens ?
-
 ?
alpha2-macroglobulin + H2O 55% cleavage Homo sapiens ?
-
 ?
chloride intracellular channel protein 1 + H2O 51% cleavage Homo sapiens ?
-
 ?
clusterin + H2O 50% cleavage Homo sapiens ?
-
 ?
fascin + H2O 40% cleavage Homo sapiens ?
-
 ?
fibromodulin + H2O 90% cleavage Homo sapiens ?
-
 ?
additional information HTRA1 does not cleave CFH protein, complement component C3 and complement component C3b Homo sapiens ?
-
 ?
talin-1 + H2O 21% cleavage Homo sapiens ?
-
 ?
Vitronectin + H2O 54% cleavage Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HtrA1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HTRA1 mRNA levels are 3fold higher in primary RPE cells homozygous for the HTRA1 promoter risk allele (rs11200638 -512 G>A), than in RPE cells with the wild type allele. This translates into a 2fold increase in HTRA1 secretion by RPE cells with the risk genotype up

General Information

General Information Comment Organism
malfunction HTRA1 is involved in complement regulation and amyloid deposition in age-related macular degeneration pathogenesis Homo sapiens