Literature summary for 3.4.21.107 extracted from

Tong, F.; Black, P.N.; Bivins, L.; Quackenbush, S.; Ctrnacta, V.; DiRusso, C.C.
Direct interaction of Saccharomyces cerevisiae Faa1p with the Omi/HtrA protease orthologue Ynm3p alters lipid homeostasis (2006), Mol. Genet. Genomics, 275, 330-343.

Search for more literature for 3.4.21.107

Cloned(Commentary)

Cloned (Comment)	Organism
co-expression of Faa1p with Omi/HtrA in the yeast two-hybrid system, interaction analysis, overview	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	disruption of the YNM3 gene encoding Ynm3p results in increased fatty acid uptake, triglyceride accumulation, and reduced expression of the fatty acid-responsive OLE1 gene encoding the essential DELTA9-acyl-CoA desaturase, as well as in increased Faa1p and Faa4p ACSL activities, strain-specific phenotypes associated with deletion of YNM3 include the inability to grow on non-fermentable carbon sources and altered cellular morphology, overview	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Faa1p + H2O	Saccharomyces cerevisiae	direct interaction of Faa1p with the Omi/HtrA protease orthologue Ynm3p alters lipid homeostasis, Ynm3p modulates fatty acid metabolism and gene regulation through negative regulation of ACSL activity, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	diverse strains, overview, YNM3 gene	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Faa1p + H2O	direct interaction of Faa1p with the Omi/HtrA protease orthologue Ynm3p alters lipid homeostasis, Ynm3p modulates fatty acid metabolism and gene regulation through negative regulation of ACSL activity, overview	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
Omi/HtrA protease orthologue Ynm3p	-	Saccharomyces cerevisiae
YNL123w	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)