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Literature summary for 3.4.21.107 extracted from

  • Oender, O.; Turkarslan, S.; Sun, D.; Daldal, F.
    Overproduction or absence of the periplasmic protease DegP severely compromises bacterial growth in the absence of the dithiol:disulfide oxidoreductase DsbA (2008), Mol. Cell. Proteomics, 7, 875-890.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
degP, DNA and amino acid sequence deterination and analysis, expression anaylsis Rhodobacter capsulatus

Protein Variants

Protein Variants Comment Organism
E384K naturally occuring single missense mutation in Rhodobacter capsulatus DsbA-null mutant revertant, the mutation leads to decreased protease activity, structural model Rhodobacter capsulatus
G217S naturally occuring single missense mutation in Rhodobacter capsulatus DsbA-null mutant revertant, the mutation leads to decreased protease activity, structural model Rhodobacter capsulatus
G392C naturally occuring single missense mutation in Rhodobacter capsulatus DsbA-null mutant revertant, the mutation leads to decreased protease activity, structural model Rhodobacter capsulatus
I120F naturally occuring single missense mutation in Rhodobacter capsulatus DsbA-null mutant revertant, the mutation leads to decreased protease activity, structural model Rhodobacter capsulatus
L373S naturally occuring single missense mutation in Rhodobacter capsulatus DsbA-null mutant revertant, the mutation leads to decreased protease activity, structural model Rhodobacter capsulatus
L382P naturally occuring single missense mutation in Rhodobacter capsulatus DsbA-null mutant revertant, the mutation leads to decreased protease activity, structural model Rhodobacter capsulatus
additional information the respiratory defect of Rhodobacter capsulatus DsbA-null mutants originates from the overproduction of the periplasmic protease DegP, which renders them temperature sensitive for growth, the mutants are viable and proficient in photosynthesis, phenotype, overview, overproduction of DegP abolishes the newly restored respiratory growth ability of the revertants in all growth media Rhodobacter capsulatus
V356M naturally occuring single missense mutation in Rhodobacter capsulatus DsbA-null mutant revertant, the mutation leads to decreased protease activity, structural model Rhodobacter capsulatus

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm
-
 Rhodobacter capsulatus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rhodobacter capsulatus DegP degrades unfolded or misfolded, secreted, and accumulated inactive proteins and is important for cell survival, especially in the absence of DsbA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rhodobacter capsulatus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information DegP degrades unfolded or misfolded, secreted, and accumulated inactive proteins and is important for cell survival, especially in the absence of DsbA Rhodobacter capsulatus ?
-
 ?

Synonyms

Synonyms Comment Organism
DegP
-
 Rhodobacter capsulatus
HtrA
-
 Rhodobacter capsulatus
protease do
-
 Rhodobacter capsulatus