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Literature summary for 3.4.21.107 extracted from

  • Flannagan, R.S.; Aubert, D.; Kooi, C.; Sokol, P.A.; Valvano, M.A.
    Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo (2007), Infect. Immun., 75, 1679-1689.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.107

Cloned(Commentary)

Cloned (Comment) Organism
a six-gene cluster in chromosome 1 encoding a two-component regulatory system and an HtrA protease Burkholderia cenocepacia

Protein Variants

Protein Variants Comment Organism
additional information insertional inactivation of the six-gene cluster in chromosome 1 including gene htrA by recombination with a suicide plasmid, pGPOMEGATp, genetic analyses and complementation studies, overview, inactivation of the htrA gene is associated with a bacterial survival defect in vivo in a rat agar bead model of chronic lung infection Burkholderia cenocepacia
S245A site-directed mutagenesis, and deletion of the HtrABCAL2829 PDZ domains result in an inactive mutant Burkholderia cenocepacia

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm the N-terminal leader of the HtrA protease is required for export to the periplasmic space Burkholderia cenocepacia
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Burkholderia cenocepacia the enzyme plays a role in the Burkholderia cenocepacia stress response, HtrABCAL2829 is required for growth of Burkholderia cenocepacia upon exposure to osmotic stress by NaCl or KCl, and thermal stress at 44°C ?
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 ?

Organism

Organism UniProt Comment Textmining
Burkholderia cenocepacia
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 a member of the Burkholderia cepacia complex, strains J2315 and K56-2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme plays a role in the Burkholderia cenocepacia stress response, HtrABCAL2829 is required for growth of Burkholderia cenocepacia upon exposure to osmotic stress by NaCl or KCl, and thermal stress at 44°C Burkholderia cenocepacia ?
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 ?

Synonyms

Synonyms Comment Organism
BCAL2829
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 Burkholderia cenocepacia
HtrA
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 Burkholderia cenocepacia
HtrA protease
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 Burkholderia cenocepacia