Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.107 extracted from

  • Hou, S.; Maccarana, M.; Min, T.H.; Strate, I.; Pera, E.M.
    The secreted serine protease HtrA1 stimulates long-range FGF signaling in the early Xenopus embryo (2007), Dev. Cell, 13, 226-241.
    View publication on PubMed
Search for more literature for 3.4.21.107

Activating Compound

Activating Compound Comment Organism Structure
dermatan sulfate triggers HtrA1-induced peteriorization, overview Xenopus laevis
heparan sulfate triggers HtrA1-induced peteriorization, overview Xenopus laevis
additional information HtrA1 is expressed in early embryo and activated by FGF signals Xenopus laevis

Cloned(Commentary)

Cloned (Comment) Organism
gene htrA1, DNA and amino acid sequence determination and analysis, expression in HEK-293T cells and secretion of the recombinant enzyme to the cell culture medium Xenopus laevis

Protein Variants

Protein Variants Comment Organism
additional information HtrA knockdown promotes anterior development and impairs mesoderm and neuronal differentiation, phenotype, overview Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion of embryo HtrA1 Xenopus laevis
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000 Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xenopus laevis HtrA1 promotes posterior development in mRNA-injected Xenopus laevis embryos, e.g. induces secondary tail-like structures, expansion of mesoderm, and formation of ectopic neurons in an FGF-dependent manner, HtrA1 activates FGF/ERK signaling and the transcription of FGF genes by cleaving proteoglycans and releasing cell surface-bound FGF ligands, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Xenopus laevis A6YFB5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo HtrA1 is expressed in early embryo and activated by FGF signals Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biglycan + H2O
-
 Xenopus laevis ?
-
 ?
glypican-4 + H2O
-
 Xenopus laevis ?
-
 ?
additional information HtrA1 promotes posterior development in mRNA-injected Xenopus laevis embryos, e.g. induces secondary tail-like structures, expansion of mesoderm, and formation of ectopic neurons in an FGF-dependent manner, HtrA1 activates FGF/ERK signaling and the transcription of FGF genes by cleaving proteoglycans and releasing cell surface-bound FGF ligands, overview Xenopus laevis ?
-
 ?
syndecan-4 + H2O
-
 Xenopus laevis ?
-
 ?

Subunits

Subunits Comment Organism
? x * 50000 Xenopus laevis

Synonyms

Synonyms Comment Organism
HtrA1
-
 Xenopus laevis