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Literature summary for 3.4.21.107 extracted from
- The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase (1990), J. Bacteriol., 172, 1791-1797.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | efficient inhibitor | Escherichia coli |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48000 | - |
SDS-PAGE | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Escherichia coli | involved in the degradation of damaged proteins | ? | - |
? | |
| Protein + H2O | Escherichia coli | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | enzyme is derived by cleavage of the first 26 amino acids of the pre-HtrA precursor polypeptide | Escherichia coli |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 90% purity | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-casein + H2O | weaker substrate than beta-casein | Escherichia coli | ? | - |
? | |
| beta-casein + H2O | better substrate than alpha-casein | Escherichia coli | ? | - |
? | |
| additional information | no substrates are: bovine serum albumin, ovalbumin, globin, insulin and other peptides that are routinely used as protease substrates | Escherichia coli | ? | - |
? | |
| additional information | involved in the degradation of damaged proteins | Escherichia coli | ? | - |
? | |
| Protein + H2O | - |
Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HtrA | - |
Escherichia coli |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.8 | 10 | proteolytic activity is largely independent of the pH | Escherichia coli |
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Release 2023.1 (January 2023)
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