BRENDA - Enzyme Database show
show all sequences of 3.4.21.106

Isolation, purification, and study of properties of recombinant hepsin from Escherichia coli

Raevskaya, A.A.; Kuznetsova, E.M.; Savvateeva, M.V.; Severin, S.E.; Biochemistry 75, 866-872 (2010)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
resveratrol
hepsin activity increases in dose-dependent manner in the presence of resveratrol
Homo sapiens
Cloned(Commentary)
Commentary
Organism
expressed in Escherichia coli strains BL21(DE3), BL21(DE3) Codon Plus RIL, and Rosetta pLysS
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
anthralin
at 0.067 mM anthralin the hepsin activity is reduced by more than 70%
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.05
-
L-Asp-L-Ala-L-Ala-L-Arg-4-nitroanilide
in 0.3M Tris-HCl, 0.3 M imidazole, and 0.5 M NaCl, pH 8.4, at 37C
Homo sapiens
0.05
-
L-Asp-L-Lys-(gamma-Cbo)-L-Pro-L-Arg-4-nitroanilide
in 0.3M Tris-HCl, 0.3 M imidazole, and 0.5 M NaCl, pH 8.4, at 37C
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42038
-
x * 42038, calculated from amino acid sequence
Homo sapiens
43000
-
x * 43000, SDS-PAGE
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
Ni-IDA.Sepharose column chromatography and Q-Sepharose column chromatography
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-Asp-L-Ala-L-Ala-L-Arg-4-nitroanilide + H2O
-
717265
Homo sapiens
L-Asp-L-Ala-L-Ala-L-Arg + 4-nitroaniline
-
-
-
?
L-Asp-L-Lys-(gamma-Cbo)-L-Pro-L-Arg-4-nitroanilide + H2O
-
717265
Homo sapiens
L-Asp-L-Lys-(gamma-Cbo)-L-Pro-L-Arg + 4-nitroaniline
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 42038, calculated from amino acid sequence; x * 43000, SDS-PAGE
Homo sapiens
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
calculated from amino acid sequence
-
7.3
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
resveratrol
hepsin activity increases in dose-dependent manner in the presence of resveratrol
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli strains BL21(DE3), BL21(DE3) Codon Plus RIL, and Rosetta pLysS
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
anthralin
at 0.067 mM anthralin the hepsin activity is reduced by more than 70%
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.05
-
L-Asp-L-Ala-L-Ala-L-Arg-4-nitroanilide
in 0.3M Tris-HCl, 0.3 M imidazole, and 0.5 M NaCl, pH 8.4, at 37C
Homo sapiens
0.05
-
L-Asp-L-Lys-(gamma-Cbo)-L-Pro-L-Arg-4-nitroanilide
in 0.3M Tris-HCl, 0.3 M imidazole, and 0.5 M NaCl, pH 8.4, at 37C
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42038
-
x * 42038, calculated from amino acid sequence
Homo sapiens
43000
-
x * 43000, SDS-PAGE
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
Ni-IDA.Sepharose column chromatography and Q-Sepharose column chromatography
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-Asp-L-Ala-L-Ala-L-Arg-4-nitroanilide + H2O
-
717265
Homo sapiens
L-Asp-L-Ala-L-Ala-L-Arg + 4-nitroaniline
-
-
-
?
L-Asp-L-Lys-(gamma-Cbo)-L-Pro-L-Arg-4-nitroanilide + H2O
-
717265
Homo sapiens
L-Asp-L-Lys-(gamma-Cbo)-L-Pro-L-Arg + 4-nitroaniline
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 42038, calculated from amino acid sequence; x * 43000, SDS-PAGE
Homo sapiens
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
calculated from amino acid sequence
-
7.3
Other publictions for EC 3.4.21.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731633
Zhang
Hepsin inhibits CDK11p58 IRES ...
Homo sapiens
Cell. Signal.
27
789-797
2015
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
731529
Khandekar
Role of hepsin in factor VII a ...
Danio rerio
Blood Cells Mol. Dis.
52
76-81
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
717225
Koschubs
Allosteric antibody inhibition ...
Homo sapiens
Biochem. J.
442
483-494
2012
-
-
1
1
-
-
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
-
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-
-
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-
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1
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1
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1
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1
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1
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
731887
Hsu
Serine protease hepsin regulat ...
Mus musculus
Hepatology
56
1913-1923
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
718105
Ganesan
Proteolytic activation of pro- ...
Homo sapiens
Mol. Cancer Res.
9
1175-1186
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
707437
Owen
Pericellular activation of hep ...
Homo sapiens
Biochem. J.
426
219-228
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
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1
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-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
707636
Nakama
Activation of rat liver micros ...
Rattus norvegicus
Biol. Pharm. Bull.
33
561-567
2010
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
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1
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-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
709925
Chen
Hepsin activates prostasin and ...
Homo sapiens
Mol. Cell. Biochem.
337
259-266
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710461
Holt
Association of hepsin gene var ...
Homo sapiens
Prostate
70
1012-1019
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710464
Nandana
Hepsin cooperates with MYC in ...
Mus musculus
Prostate
70
591-600
2010
-
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
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1
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
717265
Raevskaya
Isolation, purification, and s ...
Homo sapiens
Biochemistry
75
866-872
2010
1
-
1
-
-
-
1
2
-
-
2
-
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
1
-
2
-
-
2
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
697904
Beliveau
Probing the substrate specific ...
Homo sapiens
FEBS J.
276
2213-2226
2009
-
-
1
-
-
-
10
14
-
-
2
-
-
2
-
-
1
-
-
1
-
-
17
-
1
-
-
14
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
10
-
14
-
-
2
-
-
-
-
1
-
1
-
-
17
-
1
-
-
14
1
-
-
-
-
-
-
-
-
-
701403
Halabian
Establishment of a cell line e ...
Homo sapiens
Vox Sang.
96
309-315
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
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-
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-
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-
1
1
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1
-
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-
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-
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-
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-
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-
-
-
-
707989
Li
Pegylated kunitz domain inhibi ...
Mus musculus
Cancer Res.
69
8395-8402
2009
-
-
1
-
-
-
1
-
-
-
-
-
-
3
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
684475
Matsuo
Expression of the serine prote ...
Homo sapiens
Anticancer Res.
28
159-164
2008
-
1
-
-
-
-
-
-
-
-
-
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2
-
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-
2
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1
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-
2
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698324
Miao
Hepsin colocalizes with desmos ...
Homo sapiens
Int. J. Cancer
123
2041-2047
2008
-
-
1
-
2
-
-
-
2
-
-
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3
-
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-
-
4
-
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1
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2
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2
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4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698350
Nakamura
Hepsin inhibits the cell growt ...
Homo sapiens
Int. J. Mol. Med.
22
389-397
2008
-
-
-
-
1
-
-
-
-
-
-
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1
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1
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-
-
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-
-
-
-
-
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-
-
-
-
698824
Tripathi
Laminin-332 is a substrate for ...
Homo sapiens
J. Biol. Chem.
283
30576-30584
2008
-
1
-
-
1
-
2
-
1
-
-
-
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3
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
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1
-
-
-
1
-
-
2
-
-
1
-
-
-
-
-
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-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
684319
Guipponi
Mice deficient for the type II ...
Mus musculus
Am. J. Pathol.
171
608-616
2007
-
1
-
-
1
-
-
-
-
-
-
-
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3
-
-
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-
-
-
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1
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1
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-
-
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-
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-
-
-
686903
Wu
Hepsin and prostate cancer ...
Homo sapiens, Mus musculus, Rattus norvegicus
Front. Biosci.
12
5052-5059
2007
-
2
2
1
1
-
1
-
2
-
2
-
-
5
-
-
2
-
-
17
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
1
1
-
-
1
-
-
2
-
2
-
-
-
-
2
-
17
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674067
Nakamura
Hepsin shows inhibitory effect ...
Homo sapiens
Int. J. Oncol.
28
393-398
2006
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685451
Kunii
Purification of liver serine p ...
Rattus norvegicus
Biol. Pharm. Bull.
29
868-874
2006
-
-
-
-
-
-
11
-
1
-
6
-
-
2
-
-
1
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Hepsin promotes prostate cance ...
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