BRENDA - Enzyme Database show
show all sequences of 3.4.21.106

Variants in the HEPSIN gene are associated with prostate cancer in men of European origin

Pal, P.; Xi, H.; Kaushal, R.; Sun, G.; Jin, C.H.; Jin, L.; Suarez, B.K.; Catalona, W.J.; Deka, R.; Hum. Genet. 120, 187-192 (2006)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
association of five of eleven single nucleotide polymorphisms on the hepsin gene HPN with susceptibility to prostate cancer among men of European descent. Association of one of the single nucleotide polymorphisms with Gleason score, which suggests a role of HPN in tumor aggressiveness
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Application (protein specific)
Application
Commentary
Organism
medicine
association of five of eleven single nucleotide polymorphisms on the hepsin gene HPN with susceptibility to prostate cancer among men of European descent. Association of one of the single nucleotide polymorphisms with Gleason score, which suggests a role of HPN in tumor aggressiveness
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Other publictions for EC 3.4.21.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731633
Zhang
Hepsin inhibits CDK11p58 IRES ...
Homo sapiens
Cell. Signal.
27
789-797
2015
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1
1
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731529
Khandekar
Role of hepsin in factor VII a ...
Danio rerio
Blood Cells Mol. Dis.
52
76-81
2014
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1
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717225
Koschubs
Allosteric antibody inhibition ...
Homo sapiens
Biochem. J.
442
483-494
2012
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1
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731887
Hsu
Serine protease hepsin regulat ...
Mus musculus
Hepatology
56
1913-1923
2012
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1
1
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718105
Ganesan
Proteolytic activation of pro- ...
Homo sapiens
Mol. Cancer Res.
9
1175-1186
2011
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1
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1
1
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707437
Owen
Pericellular activation of hep ...
Homo sapiens
Biochem. J.
426
219-228
2010
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1
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707636
Nakama
Activation of rat liver micros ...
Rattus norvegicus
Biol. Pharm. Bull.
33
561-567
2010
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709925
Chen
Hepsin activates prostasin and ...
Homo sapiens
Mol. Cell. Biochem.
337
259-266
2010
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710461
Holt
Association of hepsin gene var ...
Homo sapiens
Prostate
70
1012-1019
2010
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1
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710464
Nandana
Hepsin cooperates with MYC in ...
Mus musculus
Prostate
70
591-600
2010
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1
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4
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1
1
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717265
Raevskaya
Isolation, purification, and s ...
Homo sapiens
Biochemistry
75
866-872
2010
1
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1
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2
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697904
Beliveau
Probing the substrate specific ...
Homo sapiens
FEBS J.
276
2213-2226
2009
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1
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10
14
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2
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2
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1
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1
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17
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1
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14
1
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10
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14
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2
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1
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1
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17
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1
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14
1
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-
701403
Halabian
Establishment of a cell line e ...
Homo sapiens
Vox Sang.
96
309-315
2009
-
1
1
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707989
Li
Pegylated kunitz domain inhibi ...
Mus musculus
Cancer Res.
69
8395-8402
2009
-
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1
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1
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3
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2
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1
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1
1
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-
684475
Matsuo
Expression of the serine prote ...
Homo sapiens
Anticancer Res.
28
159-164
2008
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1
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2
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698324
Miao
Hepsin colocalizes with desmos ...
Homo sapiens
Int. J. Cancer
123
2041-2047
2008
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1
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2
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2
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698350
Nakamura
Hepsin inhibits the cell growt ...
Homo sapiens
Int. J. Mol. Med.
22
389-397
2008
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698824
Tripathi
Laminin-332 is a substrate for ...
Homo sapiens
J. Biol. Chem.
283
30576-30584
2008
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1
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1
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2
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684319
Guipponi
Mice deficient for the type II ...
Mus musculus
Am. J. Pathol.
171
608-616
2007
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1
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686903
Wu
Hepsin and prostate cancer ...
Homo sapiens, Mus musculus, Rattus norvegicus
Front. Biosci.
12
5052-5059
2007
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2
2
1
1
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1
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2
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2
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5
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2
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17
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6
2
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674067
Nakamura
Hepsin shows inhibitory effect ...
Homo sapiens
Int. J. Oncol.
28
393-398
2006
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685451
Kunii
Purification of liver serine p ...
Rattus norvegicus
Biol. Pharm. Bull.
29
868-874
2006
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11
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1
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687027
Pal
Variants in the HEPSIN gene ar ...
Homo sapiens
Hum. Genet.
120
187-192
2006
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687522
Moran
Pro-urokinase-type plasminogen ...
Homo sapiens
J. Biol. Chem.
281
30439-30446
2006
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1
1
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3
1
1
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2
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1
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1
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2
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1
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1
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1
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671662
Zhang
Human hepatitis B virus X prot ...
Homo sapiens
Arch. Virol.
150
721-741
2005
-
1
1
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4
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4
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1
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4
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671835
Herter
Hepatocyte growth factor is a ...
Homo sapiens
Biochem. J.
390
125-136
2005
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1
1
1
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2
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1
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2
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1
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6
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6
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1
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6
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6
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672315
Li
Identification and characteriz ...
Homo sapiens
Biochim. Biophys. Acta
1681
157-165
2005
-
1
1
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2
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3
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2
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1
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15
-
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1
1
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