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Literature summary for 3.4.21.105 extracted from
- Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating (2015), Nature, 523, 101-105 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calcium | potently stimulates proteolysis by endogenous rhomboid-4 in cells and when rhomboid-4 is purified and reconstituted in liposomes. Calcium increases catalytic rate by promoting substrate gating | Drosophila melanogaster |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | Q9VYW6 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| rho-4 | - |
Drosophila melanogaster |
| rhomboid-4 | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | deleting the amino-terminal EF-hands activates proteolysis prematurely. Residues in cytoplasmic loops connecting distal transmembrane segments mediate calcium stimulation. Presence of calcium increases catalytic rate by promoting substrate gating. Substrates with cleavage sites outside the membrane can be cleaved but lose the capacity to be regulated | Drosophila melanogaster |
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