Literature summary for 3.4.21.105 extracted from

Vinothkumar, K.R.; Pierrat, O.A.; Large, J.M.; Freeman, M.
Structure of rhomboid protease in complex with beta-lactam inhibitors defines the S2 cavity (2013), Structure, 21, 1051-1058.

Search for more literature for 3.4.21.105

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure in complex with beta-lactam inhibitors phenyl 2-oxo-4-phenylazetidine-1-carboxylate, 2-methylpropyl 2-oxo-4-phenylazetidine-1-carboxylate, and cyclopentyl 2-oxo-4-phenylazetidine-1-carboxylate, to 2.2 to 2.4 A resolution	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
2-methylpropyl 2-oxo-4-phenylazetidine-1-carboxylate	beta-lactam inhibitor, forms a single bond to the catalytic serine and the carbonyl oxygen of the inhibitor faces away from the oxyanion hole. The hydrophobic N-substituent of the inhibitor points into a cavity within the enzyme, providing a structural explanation for the specificity of beta-lactams on rhomboid proteases. This same cavity probably represents the S2' substrate binding site	Escherichia coli
cyclopentyl 2-oxo-4-phenylazetidine-1-carboxylate	beta-lactam inhibitor, forms a single bond to the catalytic serine and the carbonyl oxygen of the inhibitor faces away from the oxyanion hole. The hydrophobic N-substituent of the inhibitor points into a cavity within the enzyme, providing a structural explanation for the specificity of beta-lactams on rhomboid proteases. This same cavity probably represents the S2' substrate binding site	Escherichia coli
phenyl 2-oxo-4-phenylazetidine-1-carboxylate	beta-lactam inhibitor, forms a single bond to the catalytic serine and the carbonyl oxygen of the inhibitor faces away from the oxyanion hole. The hydrophobic N-substituent of the inhibitor points into a cavity within the enzyme, providing a structural explanation for the specificity of beta-lactams on rhomboid proteases. This same cavity probably represents the S2' substrate binding site	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P09391	-	-

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Release 2023.1 (January 2023)