Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.105 extracted from

  • Civitarese, A.E.; MacLean, P.S.; Carling, S.; Kerr-Bayles, L.; McMillan, R.P.; Pierce, A.; Becker, T.C.; Moro, C.; Finlayson, J.; Lefort, N.; Newgard, C.B.; Mandarino, L.; Cefalu, W.; Walder, K.; Collier, G.R.; Hulver, M.W.; Smith, S.R.; Ravussin, E.
    Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL (2010), Cell Metab., 11, 412-426.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.105

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
PARL
-
 Mus musculus

General Information

General Information Comment Organism
malfunction muscle knockdown of PARL in mice results in malformed mitochondrial cristae, lower mitochondrial content, decreased PGC1alpha protein levels, and impaired insulin signaling. Suppression of PARL protein in healthy myotubes lowers mitochondrial mass and insulin-stimulated glycogen synthesis and increases reactive oxygen species production Mus musculus