Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | the intramembrane enzyme contains six transmembrane helices | Escherichia coli | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Escherichia coli | intramembrane proteolysis regulates diverse biological processes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains | active site structure and catalytic mechanism, structure-function realationship | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | intramembrane proteolysis regulates diverse biological processes | Escherichia coli | ? | - |
? | |
additional information | structural analysis of the enzyme reveals a gating mechanism for substrate entry, cleavage of substrate peptide bonds within the membrane bilayer, the catalytic Ser201 is located at the N terminus of helix alpha4 approximately 10 A below the membrane surface, structure-function realationship, overview | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the rhomboid intramembrane protease family | Escherichia coli |