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Literature summary for 3.4.21.105 extracted from
- Rhomboid proteins: conserved membrane proteases with divergent biological functions (2006), Genes Dev., 20, 3054-3068.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| phylogenetic analysis | Homo sapiens |
| phylogenetic analysis | Saccharomyces cerevisiae |
| seven rhomboid genes | Drosophila melanogaster |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme knockout strains show no phenotype | Bacillus subtilis |
| additional information | enzyme knockout strains show no phenotype | Escherichia coli |
| additional information | pcp1-deleted cells has a slow growth phenotype and contain unprocessed Mgm1 | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Arabidopsis thaliana | 5794 | - |
| Golgi membrane | intramembrane enzyme | Arabidopsis thaliana | 139 | - |
| membrane | intramembrane enzyme with seven transmembrane segments, the enzyme contains a serine proteaselike catalytic apparatus embedded within the membrane bilayer, buried in a hydrophilic cavity formed by a protein ring | Drosophila melanogaster | 16020 | - |
| mitochondrion | Rbd1 and Ygr101w | Saccharomyces cerevisiae | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytochrome c peroxidase + H2O | Saccharomyces cerevisiae | cleaving the targeting sequence of cytochrome c peroxidase, Pcp1 | processed cytochrome c peroxidase + targeting sequence peptide | - |
? |  |
| growth factor Spitz + H2O | Arabidopsis thaliana | - |
? | - |
? | |
| growth factor Spitz + H2O | Drosophila melanogaster | Rhomboid-1 is important in extracellular signal production, overview | ? | - |
? | |
| Mgm1 + H2O | Saccharomyces cerevisiae | cleaving the long isoform of Mgm1 to produce the short one | ? | - |
? | |
| additional information | Drosophila melanogaster | Rhomboid is the signal-generating component of epidermal growth factor receptor signaling during development, a metazoan developmental regulator, intramembrane proteolysis is a widespread regulatory mechanism, overview, Rhomboid-3 is important in eye development | ? | - |
? | |
| additional information | Bacillus subtilis | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
| additional information | Escherichia coli | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
| additional information | Providencia stuartii | the enzyme is important in cell signaling, mechanism, overview | ? | - |
? | |
| additional information | Toxoplasma gondii | the enzyme proteolytically cleaves adhesin-receptor complexes during parasite invasion, overview, the enzyme is important in cell sigaling, mechanism, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
contains over a dozen rhomboid-like genes | - |
| Bacillus subtilis | - |
- |
- |
| Drosophila melanogaster | - |
rhomboid gene | - |
| Escherichia coli | - |
gene glpG | - |
| Homo sapiens | - |
- |
- |
| Providencia stuartii | - |
Gram-negative human pathogen of the urinary tract, gene aarA | - |
| Saccharomyces cerevisiae | - |
- |
- |
| Toxoplasma gondii | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | Rhomboid-3 | Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytochrome c peroxidase + H2O | cleaving the targeting sequence of cytochrome c peroxidase, Pcp1 | Saccharomyces cerevisiae | processed cytochrome c peroxidase + targeting sequence peptide | - |
? | |
| growth factor Spitz + H2O | - |
Arabidopsis thaliana | ? | - |
? | |
| growth factor Spitz + H2O | Rhomboid-1 | Drosophila melanogaster | ? | - |
? | |
| growth factor Spitz + H2O | Rhomboid-1 is important in extracellular signal production, overview | Drosophila melanogaster | ? | - |
? | |
| Mgm1 + H2O | cleaving the long isoform of Mgm1 to produce the short one | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | Rhomboid is the signal-generating component of epidermal growth factor receptor signaling during development, a metazoan developmental regulator, intramembrane proteolysis is a widespread regulatory mechanism, overview, Rhomboid-3 is important in eye development | Drosophila melanogaster | ? | - |
? | |
| additional information | the enzyme is important in cell signaling, mechanism, overview | Bacillus subtilis | ? | - |
? | |
| additional information | the enzyme is important in cell signaling, mechanism, overview | Escherichia coli | ? | - |
? | |
| additional information | the enzyme is important in cell signaling, mechanism, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is important in cell signaling, mechanism, overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the enzyme is important in cell signaling, mechanism, overview | Providencia stuartii | ? | - |
? | |
| additional information | the enzyme proteolytically cleaves adhesin-receptor complexes during parasite invasion, overview, the enzyme is important in cell sigaling, mechanism, overview | Toxoplasma gondii | ? | - |
? | |
| additional information | PARL interacts with Alzheimers presenilin protein in vitro | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AarA | - |
Providencia stuartii |
| GlpG | - |
Escherichia coli |
| PARL | - |
Homo sapiens |
| PARL | - |
Saccharomyces cerevisiae |
| Pcp1 | - |
Saccharomyces cerevisiae |
| presenilin-associated rhomboid-like | - |
Homo sapiens |
| presenilin-associated rhomboid-like | - |
Saccharomyces cerevisiae |
| Rbd1 | - |
Saccharomyces cerevisiae |
| RHBDL | - |
Homo sapiens |
| Rhomboid protein | - |
Drosophila melanogaster |
| rhomboid-1 | - |
Drosophila melanogaster |
| rhomboid-2 | - |
Drosophila melanogaster |
| rhomboid-3 | - |
Drosophila melanogaster |
| rhomboid-like protein | - |
Bacillus subtilis |
| rhomboid-like protein | - |
Escherichia coli |
| rhomboid-like protein | - |
Homo sapiens |
| rhomboid-like protein | - |
Saccharomyces cerevisiae |
| rhomboid-like protein | - |
Arabidopsis thaliana |
| rhomboid-like protein | - |
Providencia stuartii |
| rhomboid-like protein | - |
Toxoplasma gondii |
| Spitz protease | - |
Drosophila melanogaster |
| Ygr101w | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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