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Literature summary for 3.4.21.105 extracted from
- A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma (2005), Proc. Natl. Acad. Sci. USA, 102, 4146-4151.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | TgROM5 is able to cleave MIC adhesins. It likely provides the key protease activity necessary for invasion. The enzyme TgROM5 offers a target for therapeutic intervention against invasion by the deadly pathogen Toxoplasma gondii | Toxoplasma gondii |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | TgROM4 is localized to the cell surface | Toxoplasma gondii | 9986 | - |
| cell surface | TgROM5 is localized to the cell surface, primarily at the posterior of the parasite | Toxoplasma gondii | 9986 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| MIC adhesin + H2O | Toxoplasma gondii | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? |  |
| MIC adhesin + H2O | Toxoplasma gondii TgROM2 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
| MIC adhesin + H2O | Toxoplasma gondii TgROM1 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
| MIC adhesin + H2O | Toxoplasma gondii TgROM3 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
| MIC adhesin + H2O | Toxoplasma gondii TgROM5 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
| MIC adhesin + H2O | Toxoplasma gondii TgROM4 | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Toxoplasma gondii | - |
TgROM1 | - |
| Toxoplasma gondii | - |
TgROM2 | - |
| Toxoplasma gondii | - |
TgROM3 | - |
| Toxoplasma gondii | - |
TgROM4 | - |
| Toxoplasma gondii | - |
TgROM5 | - |
| Toxoplasma gondii TgROM1 | - |
TgROM1 | - |
| Toxoplasma gondii TgROM2 | - |
TgROM2 | - |
| Toxoplasma gondii TgROM3 | - |
TgROM3 | - |
| Toxoplasma gondii TgROM4 | - |
TgROM4 | - |
| Toxoplasma gondii TgROM5 | - |
TgROM5 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| oocyte | TgROM2 | Toxoplasma gondii | - |
| oocyte | TgROM3 | Toxoplasma gondii | - |
| tachyzoite | TgROM1 | Toxoplasma gondii | - |
| tachyzoite | TgROM4 is localized to the cell surface | Toxoplasma gondii | - |
| tachyzoite | TgROM5 is localized to the cell surface, primarily at the posterior of the parasite | Toxoplasma gondii | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| MIC adhesin + H2O | - |
Toxoplasma gondii | ? | - |
? | |
| MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii | ? | - |
? | |
| MIC adhesin + H2O | - |
Toxoplasma gondii TgROM2 | ? | - |
? | |
| MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM2 | ? | - |
? | |
| MIC adhesin + H2O | - |
Toxoplasma gondii TgROM1 | ? | - |
? | |
| MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM1 | ? | - |
? | |
| MIC adhesin + H2O | - |
Toxoplasma gondii TgROM3 | ? | - |
? | |
| MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM3 | ? | - |
? | |
| MIC adhesin + H2O | - |
Toxoplasma gondii TgROM5 | ? | - |
? | |
| MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM5 | ? | - |
? | |
| MIC adhesin + H2O | - |
Toxoplasma gondii TgROM4 | ? | - |
? | |
| MIC adhesin + H2O | only TgRMO5 is able to cleave MIC adhesins, it likely provides the key protease activity necessary for invasion | Toxoplasma gondii TgROM4 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TgROM1 | - |
Toxoplasma gondii |
| TgROM2 | - |
Toxoplasma gondii |
| TgROM3 | - |
Toxoplasma gondii |
| TgROM4 | - |
Toxoplasma gondii |
| TgROM5 | - |
Toxoplasma gondii |
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