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Literature summary for 3.4.21.105 extracted from

  • Walder, K.; Kerr-Bayles, L.; Civitarese, A.; Jowett, J.; Curran, J.; Elliott, K.; Trevaskis, J.; Bishara, N.; Zimmet, P.; Mandarino, L.; Ravussin, E.; Blangero, J.; Kissebah, A.; Collier, G.R.
    The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes (2005), Diabetologia, 48, 459-468.
    View publication on PubMed

Application

Application Comment Organism
medicine variation in rhomboid protease PSARL sequence and/or expression may be an important new risk factor for type 2 diabetes and other components of the metabolic syndrome Homo sapiens

Protein Variants

Protein Variants Comment Organism
L262V genetic variation is associated with insulin-resistance in an age-dependent manner Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion intramembrane enzyme Homo sapiens 5739
-
mitochondrion intramembrane enzyme Psammomys obesus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Psammomys obesus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle expression is reduced in diabetic Psammomys obesus, and restored after exercise training to successfully treat the diabetes Psammomys obesus
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skeletal muscle vastus lateralis. Expression of rhomboid protease PSARL is associated with mitochondrial oxidative capacity and insulin sensitivity Homo sapiens
-

Synonyms

Synonyms Comment Organism
PSARL
-
Homo sapiens
PSARL
-
Psammomys obesus
rhomboid protease PSARL
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Homo sapiens
rhomboid protease PSARL
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Psammomys obesus