Crystallization (Comment) | Organism |
---|---|
in complex with Schistocerca gregaria protease inhibitor-2 variant VCTKLWCN, to 1.28 A resolution. Strucutre reveals significant plasticity of the protease | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Schistocerca gregaria protease inhibitor-2 variant FCTRKLCY | randomization of positions P4, P2, P1, P1', P2', and P4' of the protease binding loop while keeping the structurally indispensable Cys at P3 and P3' leads to monospecific MASP inhibitors. Inhibitor variant FCTRKLCY is specific for isoform MASP-1 | Homo sapiens | |
Schistocerca gregaria protease inhibitor-2 variant VCTKLWCN | randomization of positions P4, P2, P1, P1', P2', and P4' of the protease binding loop while keeping the structurally indispensable Cys at P3 and P3' leads to monospecific MASP inhibitors. MASP-2 inhibitor variant VCTKLWCN completely blocks the lectin pathway activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00187 | - |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000006 | - |
Schistocerca gregaria protease inhibitor-2 variant VCTKLWCN | pH not specified in the publication, temperature not specified in the publication | Homo sapiens | |
0.058 | - |
Schistocerca gregaria protease inhibitor-2 variant FCTRKLCY | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |