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Literature summary for 3.4.21.104 extracted from
- TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2 (2015), Eur. J. Immunol., 45, 544-550.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Kunitz-type inhibitor tissue factor pathway inhibitor | selective inhibitor of enzyme Masp-2, without affecting MASP-1 or the classical pathway proteases C1s and C1r. Kunitz-2 domain of the inhibitor is required for the inhibition of MASP-2 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? |  |
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Release 2023.1 (January 2023)
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