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Literature summary for 3.4.21.104 extracted from

  • Gulla, K.C.; Gupta, K.; Krarup, A.; Gal, P.; Schwaeble, W.J.; Sim, R.B.; OConnor, C.D.; Hajela, K.
    Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot (2010), Immunology, 129, 482-495.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
ficolin
-
Homo sapiens
mannose-binding lectin
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information hirudin does not inhibit MASP-2 Homo sapiens
pefabloc i.e. 4-(2-aminoethyl)-benzenesulphonyl fluoride Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
77000
-
MASP-2, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XIII + H2O Homo sapiens
-
factor XIIIa + ?
-
?
fibrinogen + H2O Homo sapiens
-
fibrin + ?
-
?
additional information Homo sapiens MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII ?
-
?
prothrombin + H2O Homo sapiens
-
thrombin + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
mannan-agarose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XIII + H2O
-
Homo sapiens factor XIIIa + ?
-
?
fibrinogen + H2O
-
Homo sapiens fibrin + ?
-
?
additional information MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII Homo sapiens ?
-
?
prothrombin + H2O
-
Homo sapiens thrombin + ?
-
?

Synonyms

Synonyms Comment Organism
mannan-binding lectin-associated serine protease
-
Homo sapiens
Map19 MASP-2 exists in an alternatively spliced form, known as Map19 Homo sapiens
MASP-2
-
Homo sapiens
MBL-MASP
-
Homo sapiens