Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ficolin | - |
Homo sapiens | |
mannose-binding lectin | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | hirudin does not inhibit MASP-2 | Homo sapiens | |
pefabloc | i.e. 4-(2-aminoethyl)-benzenesulphonyl fluoride | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
77000 | - |
MASP-2, gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XIII + H2O | Homo sapiens | - |
factor XIIIa + ? | - |
? | |
fibrinogen + H2O | Homo sapiens | - |
fibrin + ? | - |
? | |
additional information | Homo sapiens | MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII | ? | - |
? | |
prothrombin + H2O | Homo sapiens | - |
thrombin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
mannan-agarose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor XIII + H2O | - |
Homo sapiens | factor XIIIa + ? | - |
? | |
fibrinogen + H2O | - |
Homo sapiens | fibrin + ? | - |
? | |
additional information | MBL-MASP complexes, bound to mannan-agarose, generate clots when incubated with calcified plasma or purified fibrinogen and factor XIII | Homo sapiens | ? | - |
? | |
prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mannan-binding lectin-associated serine protease | - |
Homo sapiens |
Map19 | MASP-2 exists in an alternatively spliced form, known as Map19 | Homo sapiens |
MASP-2 | - |
Homo sapiens |
MBL-MASP | - |
Homo sapiens |