Literature summary for 3.4.21.104 extracted from

Swierzko, A.S.; Cedzynski, M.; Domzalska-Popadiuk, I.; Macdonald, S.L.; Borkowska-Klos, M.; Atkinson, A.P.; Szala, A.; Jopek, A.; Jensenius, J.C.; Kawakami, M.; Szczapa, J.; Matsushita, M.; Szemraj, J.; Turner, M.L.; Kilpatrick, D.C.
Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations (2009), Mol. Immunol., 46, 1696-1701.

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Protein Variants

Protein Variants	Comment	Organism
D120G	among 362 samples tested for the D120G single nucleotide polymorphism of the MASP2 gene, no homozygote for that mutation is found. Heterozygosity for this allele significantly influences the protein concentration, but not the lectin pathway of complement activity (MBL-MASP-2 complex activity). No association of this single nucleotide polymorphism is apparent with prematurity, low birth weight or perinatal infections	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	cord blood MASP-2 concentrations in a large, ethnically homogeneous cohort of neonates is investigated: Serum MASP-2 concentrations correlate with gestational age and birth weight and are significantly lower in premature babies and other pre-term babies compared with term babies. Neonates with MASP-2 concentrations below 42 ng/ml are deemed to be MASP-2 deficient. That group has a shorter mean gestational age and a higher incidence of premature and low birth weight babies, but not of perinatal infections when compared with the others. There is a trend towards higher MASP-2 concentrations amongst babies with infections	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MASP-2	-	Homo sapiens

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Release 2023.1 (January 2023)