Cloned (Comment) | Organism |
---|---|
expression of mutant enzyme R424K in CHO cells | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a truncated active enzyme form | Rattus norvegicus |
R424K | site-directed mutagenesis, mutation at the zymogen cleavage site, yielding an active form of MASP2 that is secreted as zymogen but is more stable than wild-type MASP2, since it only autoactivates in complex with MBL upon binding to a suitable surface | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C2 + H2O | Rattus norvegicus | - |
? | - |
? | |
complement component C4 + H2O | Rattus norvegicus | - |
? | - |
? | |
additional information | Rattus norvegicus | the enzyme is part of the lectin pathway of the complement system, it is also capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin | ? | - |
? | |
plasminogen + H2O | Rattus norvegicus | activation | plasmin + propeptide of thrombin | - |
? | |
prekallikrein + H2O | Rattus norvegicus | activation | kallikrein + propeptide of thrombin | - |
? | |
prothrombin + H2O | Rattus norvegicus | activation of thrombin covalentyl bound to a bacterial cell surface | thrombin + propeptide of thrombin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
complement component C4 + H2O | - |
Rattus norvegicus | ? | - |
? | |
additional information | the enzyme is part of the lectin pathway of the complement system, it is also capable of promoting fibrinogen turnover by cleavage of prothrombin, generating thrombin | Rattus norvegicus | ? | - |
? | |
additional information | MASP2 acts in a mannan-bound MBL/MASP2 complex | Rattus norvegicus | ? | - |
? | |
Phe-Pro-Arg-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | ? | - |
? | |
plasminogen + H2O | - |
Rattus norvegicus | plasmin + propeptide of thrombin | - |
? | |
plasminogen + H2O | activation | Rattus norvegicus | plasmin + propeptide of thrombin | - |
? | |
prekallikrein + H2O | - |
Rattus norvegicus | kallikrein + propeptide of thrombin | - |
? | |
prekallikrein + H2O | activation | Rattus norvegicus | kallikrein + propeptide of thrombin | - |
? | |
prothrombin + H2O | activation of thrombin covalentyl bound to a bacterial cell surface | Rattus norvegicus | thrombin + propeptide of thrombin | - |
? | |
prothrombin + H2O | cleavage scheme, overview | Rattus norvegicus | thrombin + propeptide of thrombin | - |
? | |
Val-Leu-Lys-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MASP2 | - |
Rattus norvegicus |
MBL-associated serine protease 2 | - |
Rattus norvegicus |