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Literature summary for 3.4.21.10 extracted from
- Studies on ram acrosin. Isolation from spermatozoa, activation by cations and organic solvents, and influence of cations on its reaction with inhibitors (1975), Biochem. J., 149, 133-146.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activated by 2-methylpropan-2-ol, dimethyl sulfoxide and some other water-miscible solvents | Ovis aries |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aprotinin | - |
Ovis aries |  |
| benzamidine | - |
Ovis aries | |
| butan-1-ol | - |
Ovis aries | |
| Ca2+ | - |
Ovis aries | |
| additional information | inhibited by naturally occuring trypsin inhibitors, esterolytic activity, competitively inhibited by L-arginine but not by L-lysine | Ovis aries |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Ovis aries | |
| 0.021 | - |
toluene-p-sulfonyl-L-arginine methyl ester | - |
Ovis aries | |
| 0.28 | - |
Nalpha-benzoyl-L-arginine ethyl ester hydrochloride | - |
Ovis aries | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | peripheral | Ovis aries | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Ovis aries | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Ovis aries | digestion of zona pellucida by sperm, glycoprotein layer surrounding the oocyte | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | - |
beta-acrosin, psi-acrosin | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| semen | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | digestion of zona pellucida by sperm, glycoprotein layer surrounding the oocyte | Ovis aries | ? | - |
? | |
| Nalpha-benzoyl-L-arginine ethyl ester + H2O | - |
Ovis aries | ? | - |
? | |
| Nalpha-benzoyl-L-arginine ethyl ester hydrochloride + H2O | - |
Ovis aries | ? | - |
? | |
| toluene-p-sufonyl-L-arginine methyl ester + H2O | - |
Ovis aries | ? | - |
? | |
| toluene-p-sulfonyl-L-arginine methyl ester + H2O | - |
Ovis aries | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Ovis aries | |
| 49 | - |
methyl N2-[(4-methylphenyl)sulfonyl]-L-argininate | - |
Ovis aries | |
| 115 | 162 | Nalpha-benzoyl-L-Arg ethyl ester | - |
Ovis aries | |
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