Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | gamma-glutamyl hydrolase overexpression decreases global DNA methylation and DNA methyltransferase activity, while gamma-glutamyl hydrolase inhibition increases global DNA methylation and DNA methyltransferase activity. gamma-Glutamyl hydrolase modulation influences CpG promoter DNA methylation and gene expression involved in important biological pathways including cell cycle, cellular development, and cellular growth and proliferation | Homo sapiens | - |
MDA-MB-435 cell | gamma-glutamyl hydrolase overexpression decreases global DNA methylation and DNA methyltransferase activity, while gamma-glutamyl hydrolase inhibition increases global DNA methylation and DNA methyltransferase activity. gamma-Glutamyl hydrolase modulation influences CpG promoter DNA methylation and gene expression involved in important biological pathways including cell cycle, cellular development, and cellular growth and proliferation | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | gamma-Glutamyl hydrolase modulation-induced changes in total intracellular folate concentrations and content of long-chain folyl-polyglutamates are associated with functionally significant DNA methylation alterations in important biological pathways including cell cycle, cellular development, and cellular growth and proliferation | Homo sapiens |