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Literature summary for 3.4.19.9 extracted from

  • Kim, S.E.; Hinoue, T.; Kim, M.S.; Sohn, K.J.; Cho, R.C.; Cole, P.D.; Weisenberger, D.J.; Laird, P.W.; Kim, Y.I.
    gamma-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells (2015), Genes Nutr., 10, 444.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell gamma-glutamyl hydrolase overexpression decreases global DNA methylation and DNA methyltransferase activity, while gamma-glutamyl hydrolase inhibition increases global DNA methylation and DNA methyltransferase activity. gamma-Glutamyl hydrolase modulation influences CpG promoter DNA methylation and gene expression involved in important biological pathways including cell cycle, cellular development, and cellular growth and proliferation Homo sapiens
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MDA-MB-435 cell gamma-glutamyl hydrolase overexpression decreases global DNA methylation and DNA methyltransferase activity, while gamma-glutamyl hydrolase inhibition increases global DNA methylation and DNA methyltransferase activity. gamma-Glutamyl hydrolase modulation influences CpG promoter DNA methylation and gene expression involved in important biological pathways including cell cycle, cellular development, and cellular growth and proliferation Homo sapiens
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General Information

General Information Comment Organism
physiological function gamma-Glutamyl hydrolase modulation-induced changes in total intracellular folate concentrations and content of long-chain folyl-polyglutamates are associated with functionally significant DNA methylation alterations in important biological pathways including cell cycle, cellular development, and cellular growth and proliferation Homo sapiens