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Literature summary for 3.4.19.9 extracted from

  • Kim, S.E.; Cole, P.D.; Cho, R.C.; Ly, A.; Ishiguro, L.; Sohn, K.J.; Croxford, R.; Kamen, B.A.; Kim, Y.I.
    gamma-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate (2013), Br. J. Cancer, 109, 2175-2188.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine overexpression of gamma-glutamyl hydrolase significantly decreases chemosensitivity of MDA-MB-435 cells to 5-fluorouracil and methotrexate at all folate concentrations as expected. In contrast, in HCT116 cells this predicted effect is observed only at very high folate concentration, and as the folate concentration decreases this effect becomes null or paradoxically increases. Inhibition of gamma-glutamyl hydrolase significantly increases chemosensitivity of both cancer cells to 5-fluorouracil at all folate concentrations. gamma-Glutamyl hydrolase inhibition significantly decreases chemosensitivity of both cancer cells to methotrexate at all folate concentrations. In both modulation systems and cell lines, the magnitude of chemosensitivity effect incrementally increases as folate concentration increases Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
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Homo sapiens
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MDA-MB-435 cell
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Homo sapiens
-

General Information

General Information Comment Organism
physiological function overexpression of gamma-glutamyl hydrolase significantly decreases chemosensitivity of MDA-MB-435 cells to 5-fluorouracil and methotrexate at all folate concentrations as expected. In contrast, in HCT116 cells this predicted effect is observed only at very high folate concentration, and as the folate concentration decreases this effect becomes null or paradoxically increases. Inhibition of gamma-glutamyl hydrolase significantly increases chemosensitivity of both cancer cells to 5-fluorouracil at all folate concentrations. gamma-Glutamyl hydrolase inhibition significantly decreases chemosensitivity of both cancer cells to methotrexate at all folate concentrations. In both modulation systems and cell lines, the magnitude of chemosensitivity effect incrementally increases as folate concentration increases Homo sapiens