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Literature summary for 3.4.19.9 extracted from

  • Scorpio, A.; Chabot, D.J.; Day, W.A.; Obrien, D.K.; Vietri, N.J.; Itoh, Y.; Mohamadzadeh, M.; Friedlander, A.M.
    Poly-gamma-glutamate capsule-degrading enzyme treatment enhances phagocytosis and killing of encapsulated Bacillus anthracis (2007), Antimicrob. Agents Chemother., 51, 215-222.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.19.9

Activating Compound

Activating Compound Comment Organism Structure
additional information erythromycin slightly stimulates the enzyme-mediated phagocytosis Bacillus phage phiNIT1

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ Zn2+ or Mn2+ are required Bacillus phage phiNIT1
Zn2+ Zn2+ or Mn2+ are required Bacillus phage phiNIT1

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
 x * 25000 Bacillus phage phiNIT1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacillus phage phiNIT1 the enzyme specifically cleaves D- and L-polyglutamic acid, preferred to entirely of poly-D-glutamic acid, a component of the capsule produced by several strains of Bacillus subtilis, the enzyme has minimal activity in degrading Bacillus anthracis and to remove the capsule from the surface of bacilli, the poly-gamma-D-glutamic acid capsule, no effect on RAW264.7 murine macrophage phagocytosis, and only minimal enhancement of human host neutrophil killing ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus phage phiNIT1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme specifically cleaves D- and L-polyglutamic acid, preferred to entirely of poly-D-glutamic acid, a component of the capsule produced by several strains of Bacillus subtilis, the enzyme has minimal activity in degrading Bacillus anthracis and to remove the capsule from the surface of bacilli, the poly-gamma-D-glutamic acid capsule, no effect on RAW264.7 murine macrophage phagocytosis, and only minimal enhancement of human host neutrophil killing Bacillus phage phiNIT1 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 25000 Bacillus phage phiNIT1

Synonyms

Synonyms Comment Organism
gamma-polyglutamic acid hydrolase
-
 Bacillus phage phiNIT1
PghP
-
 Bacillus phage phiNIT1

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bacillus phage phiNIT1

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bacillus phage phiNIT1