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Literature summary for 3.4.19.6 extracted from
- Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency (2015), Int. J. Dev. Neurosci., 46, 115-124 .
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | Zn2+-dependent metallopeptidase | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q10836 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adenohypophysis | - |
Rattus norvegicus | - |
| hypothalamus | medial-basal-hypothalamus | Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PPII | - |
Rattus norvegicus |
| TRH-degrading enzyme | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | long-term changes in dietary Zn down-regulate pyroglutamyl aminopeptidase II activity independently of triiodothyronine, increasing thyrotropin serum concentration, overall resembling sub-clinical hypothyroidism | Rattus norvegicus |
| physiological function | the enzyme degrades thyrotropin-releasing hormone (TRH) released from the median eminence and participates in hypothalamus-pituitary-thyroid (HPT) axis function by regulating TRH-induced thyrotropin release from adenohypophysis | Rattus norvegicus |
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