BRENDA - Enzyme Database
show all sequences of 3.4.19.6

Effects of orchidectomy and testosterone replacement on mouse pyrrolidone carboxypeptidase activity in the HPA axis

Garcia-Lopez, M.J.; Martinez-Martos, J.M.; Mayas, M.D.; Carrera, M.P.; Ramirez-Exposito, M.J.; Horm. Metab. Res. 36, 131-135 (2004)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
bound to
Mus musculus
16020
-
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
orchidectomy increases activity of pyrrolidone carboxypeptidase type II, testosterone replacement returns it to control levels
Mus musculus
-
hypothalamus
-
Mus musculus
-
pituitary gland
no change in pyrrolidone carboxypeptidase type II after orchidectomy, activity increases after administration of testosterone
Mus musculus
-
Synonyms
Synonyms
Commentary
Organism
pyrrolidone carboxypeptidase type II
-
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
bound to
Mus musculus
16020
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
orchidectomy increases activity of pyrrolidone carboxypeptidase type II, testosterone replacement returns it to control levels
Mus musculus
-
hypothalamus
-
Mus musculus
-
pituitary gland
no change in pyrrolidone carboxypeptidase type II after orchidectomy, activity increases after administration of testosterone
Mus musculus
-
Other publictions for EC 3.4.19.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
753360
Ramirez-Exposito
-
High cholesterol intake modif ...
Mus musculus
Curr. Top. Pept. Protein Res.
18
103-108
2017
-
-
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-
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1
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2
-
1
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8
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3
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1
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1
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8
-
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3
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-
1
1
-
-
-
753437
Lazcano
Fasting enhances pyroglutamyl ...
Rattus norvegicus
Endocrinology
156
2713-2723
2015
-
-
-
-
-
-
-
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-
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8
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5
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5
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2
2
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753886
Alvarez-Salas
Mediobasal hypothalamic and a ...
Rattus norvegicus
Int. J. Dev. Neurosci.
46
115-124
2015
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1
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5
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2
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2
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2
2
-
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731566
Rodriguez-Molina
TRH regulates action potential ...
Rattus norvegicus
Brain Res.
1571
1-11
2014
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1
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1
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1
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-
1
1
-
-
-
731719
Alvarez-Salas
Food-restricted and dehydrated ...
Rattus norvegicus
Endocrinology
153
4067-4076
2012
-
2
-
-
-
-
-
-
-
-
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-
6
-
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732377
Lazcano
Pyroglutamyl peptidase II inhi ...
Rattus norvegicus
J. Pharmacol. Exp. Ther.
342
222-231
2012
-
-
-
-
-
-
2
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6
-
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3
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3
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-
1
1
-
-
-
697633
Sanchez
Tanycyte pyroglutamyl peptidas ...
Rattus norvegicus
Endocrinology
150
2283-2291
2009
1
-
-
-
-
-
-
-
1
-
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5
-
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3
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2
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700461
Rodriguez-Molina
NMDA receptor up-regulates pyr ...
Rattus norvegicus
Neurosci. Lett.
449
211-214
2009
1
-
-
-
-
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1
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-
1
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7
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9
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1
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2
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1
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1
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1
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9
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1
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-
689990
Gutierrez-Mariscal
Analysis of the anxiolytic-lik ...
Rattus norvegicus
Psychoneuroendocrinology
33
198-213
2008
-
1
-
-
-
-
-
-
-
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-
-
6
-
-
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-
-
1
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1
-
1
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1
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1
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1
-
-
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-
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-
-
-
-
699721
Matziari
Synthesis of the phosphinic an ...
Mammalia
J. Org. Chem.
73
8591-8593
2008
-
1
-
-
-
-
1
-
-
1
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-
1
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1
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2
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1
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1
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1
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1
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-
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-
700583
Cruz
Anterior pituitary pyroglutamy ...
Rattus norvegicus
Peptides
29
1953-1964
2008
-
-
-
-
-
-
2
-
1
-
-
1
-
1
-
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-
-
2
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3
-
2
1
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1
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2
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1
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1
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2
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3
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1
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1
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-
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-
683791
de Gortari
Stage-specific modulation of n ...
Rattus norvegicus
J. Mol. Neurosci.
33
252-261
2007
-
-
-
-
-
-
6
2
-
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5
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1
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2
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2
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6
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6
6
2
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1
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2
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689171
Aguilar-Valles
The expression of TRH, its rec ...
Rattus norvegicus
Neurochem. Int.
50
404-417
2007
-
-
-
-
-
-
1
-
-
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1
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2
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1
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1
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2
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1
-
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-
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-
-
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-
-
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-
689202
Scalabrino
Discovery of a dual action fir ...
Rattus norvegicus
Neuropharmacology
52
1472-1481
2007
-
-
-
-
-
-
6
2
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
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-
6
-
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6
6
2
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1
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2
-
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-
-
-
669472
Chavez-Gutierrez
Homology modeling and site-dir ...
Rattus norvegicus
J. Biol. Chem.
281
18581-18590
2006
-
-
-
-
6
-
-
2
1
-
1
-
-
5
-
-
-
-
-
1
-
-
1
-
1
-
-
-
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-
6
-
-
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-
2
1
-
1
-
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-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670390
de Gortari
Amygdala kindling differential ...
Rattus norvegicus
Neurochem. Int.
48
31-42
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
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1
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1
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1
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667505
Kelly
Structure-activity studies wit ...
Rattus norvegicus
Biochem. J.
389
569-576
2005
-
-
-
-
-
-
45
-
-
-
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-
3
-
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-
2
-
-
3
-
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-
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-
46
-
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-
-
-
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45
46
-
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-
-
-
-
2
-
-
3
-
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-
-
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-
-
-
669931
Chavez-Gutierrez
A truncated isoform of pyroglu ...
Rattus norvegicus
J. Neurochem.
92
807-817
2005
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
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-
-
-
-
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1
-
1
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1
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1
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1
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1
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-
647288
Pascual
Purification of a specific inh ...
Mus musculus, Rattus norvegicus
Int. J. Biochem. Cell Biol.
36
138-152
2004
-
-
-
-
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3
-
1
-
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-
-
32
-
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15
-
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1
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3
1
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1
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15
-
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-
-
668870
Garcia-Lopez
Effects of orchidectomy and te ...
Mus musculus
Horm. Metab. Res.
36
131-135
2004
-
-
-
-
-
-
-
-
1
-
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1
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3
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1
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1
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3
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647286
Schmitmeier
Purification and characterizat ...
Bos taurus, Rattus norvegicus, Sus scrofa
Eur. J. Biochem.
269
1278-1286
2002
-
-
-
-
-
-
-
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3
-
2
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5
-
2
1
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9
-
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2
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3
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2
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2
1
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9
-
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2
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647285
Kelly
Kinetic investigation of the s ...
Sus scrofa
J. Biol. Chem.
275
16746-16751
2000
-
1
-
-
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8
6
-
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3
-
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1
-
-
1
-
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10
-
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-
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-
6
-
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-
1
-
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-
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8
6
6
-
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-
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-
1
-
1
-
-
10
-
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647287
Papadopoulos
Analysis of the thyrotropin-re ...
Rattus norvegicus
Eur. J. Biochem.
267
2617-2623
2000
-
-
1
-
6
-
-
4
-
-
2
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1
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-
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1
2
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1
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1
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6
-
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4
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2
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1
2
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1
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-
95299
Gallagher
A study of a highly specific p ...
Bos taurus
Int. J. Biochem. Cell Biol.
30
115-133
1998
1
-
-
-
-
3
28
2
1
4
1
-
-
1
-
-
1
-
-
1
1
1
3
1
-
1
1
4
-
1
1
1
-
12
-
-
1
-
-
-
-
-
3
-
28
12
2
1
4
1
-
-
-
-
1
-
1
1
1
3
1
1
1
4
-
1
1
1
-
-
-
-
-
-
-
647283
Bauer
Purification and characterizat ...
Rattus norvegicus, Sus scrofa
Eur. J. Biochem.
224
387-396
1994
-
-
-
-
-
4
4
2
2
-
3
-
-
2
-
2
2
-
-
2
2
1
4
2
-
-
-
-
2
-
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-
-
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-
-
-
4
-
8
-
2
2
-
3
-
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-
2
2
-
2
2
1
4
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
647278
Elmore
Further characterization of th ...
Cavia porcellus
Neuropeptides
15
31-36
1990
-
-
-
-
-
-
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-
1
-
-
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-
1
-
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13
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