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Literature summary for 3.4.19.14 extracted from
- gamma-Glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D4 formation in vivo (2002), Am. J. Pathol., 161, 481-490.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 20000 | - |
1 * 57000 + 1 * 20000, SDS-PAGE | Mus musculus |
| 57000 | - |
1 * 57000 + 1 * 20000, SDS-PAGE | Mus musculus |
| 63000 | - |
predicted from amino acid sequence | Mus musculus |
| 75000 | - |
gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | the enzyme localizes to capillaries and sinusoids in most organs and in lung to larger vessels as well | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene C4 + H2O | - |
Mus musculus | leukotriene D4 + L-glutamate | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 57000 + 1 * 20000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gamma-glutamyl leukotrienase | - |
Mus musculus |
| GGL | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | gamma-glutamyl leukotrienase-deficient mice show leukotriene C4 accumulation and significantly more airway hyperreponsiveness than wild-type mice in the experimental asthma | Mus musculus |
| physiological function | in vivo gamma-glutamyl leukotrienase, and notgamma-glutamyl transpeptidase, is primarily responsible for conversion of leukotriene C4 to leukotriene D4. The enzyme plays an important role in inflammatory processes | Mus musculus |
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Release 2023.1 (January 2023)
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