Literature summary for 3.4.19.13 extracted from

Zhang, G.; Ducatelle, R.; Pasmans, F.; DHerde, K.; Huang, L.; Smet, A.; Haesebrouck, F.; Flahou, B.
Effects of Helicobacter suis gamma-glutamyl transpeptidase on lymphocytes: modulation by glutamine and glutathione supplementation and outer membrane vesicles as a putative delivery route of the enzyme (2013), PLoS ONE, 8, e77966.

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Application

Application	Comment	Organism
medicine	lysate from a gamma-glutamyl transpeptidase Ggt mutant strain shows a decrease of the capacity to inhibit Jurkat T cell proliferation. Incubation of Jurkat T cells with recombinantly expressed Ggt results in an impaired proliferation, and cell death is involved. A similar but more pronounced inhibitory effect is also seen on primary murine CD4+ T cells, CD8+ T cells, and CD19+ B cells. Supplementation with glutamine restores normal proliferation of the cells, whereas supplementation with reduced glutathione strengthens the enzyme-mediated inhibition of proliferation. Ggt treatment abolishes secretion of IL-4 and IL-17 by CD4+ T cells, without affecting secretion of IFN-gamma. Helicobacter suis outer membrane vesicles are a possible delivery route of Ggt to lymphocytes residing in the deeper mucosal layers	Helicobacter suis

Organism

Organism	UniProt	Comment	Textmining
Helicobacter suis	D5LUP7	-	-

Synonyms

Synonyms	Comment	Organism
GGT	-	Helicobacter suis

General Information

General Information	Comment	Organism
physiological function	lysate from a gamma-glutamyl transpeptidase Ggt mutant strain shows a decrease of the capacity to inhibit Jurkat T cell proliferation. Incubation of Jurkat T cells with recombinantly expressed Ggt results in an impaired proliferation, and cell death is involved. A similar but more pronounced inhibitory effect is also seen on primary murine CD4+ T cells, CD8+ T cells, and CD19+ B cells. Supplementation with glutamine restores normal proliferation of the cells, whereas supplementation with reduced glutathione strengthens the enzyme-mediated inhibition of proliferation. Ggt treatment abolishes secretion of IL-4 and IL-17 by CD4+ T cells, without affecting secretion of IFN-gamma. Helicobacter suis outer membrane vesicles are a possible delivery route of Ggt to lymphocytes residing in the deeper mucosal layers	Helicobacter suis

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Release 2023.1 (January 2023)