Literature summary for 3.4.19.13 extracted from

Nakajima, M.; Watanabe, B.; Han, L.; Shimizu, B.; Wada, K.; Fukuyama, K.; Suzuki, H.; Hiratake, J.
Glutathione-analogous peptidyl phosphorus esters as mechanism-based inhibitors of gamma-glutamyl transpeptidase for probing cysteinyl-glycine binding site (2014), Bioorg. Med. Chem., 22, 1176-1194.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2RS)-2-amino-4-((R)-1-[N-(carboxymethyl)carbamoyl]-2-chloroethyl(phenyl)-phosphono)butanoic acid	potent and irreversible inhibitor of enzyme, second-order rate constant value 188 per M and s, and good mimic of the putative transition state	Escherichia coli
(2RS)-2-amino-4-((S)-1-[N-(carboxymethyl)carbamoyl]-2-phenylethyl(phenyl)-phosphono)butanoic acid	potent and irreversible inhibitor of enzyme, second-order rate constant value 389 per M and s, and good mimic of the putative transition state	Escherichia coli
(2RS)-2-amino-4-((S)-1-[N-(carboxymethyl)carbamoyl]propyl(phenyl)-phosphono)butanoic acid	potent and irreversible inhibitor of human enzyme, second-order rate constant value 145 per M and s, and good mimic of the putative transition state	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-(gamma-L-glutamylamino)-4-methylcoumarin + H2O	-	Escherichia coli	7-amino-4-methylcoumarin + L-glutamate	-	?
7-(gamma-L-glutamylamino)-4-methylcoumarin + H2O	-	Homo sapiens	7-amino-4-methylcoumarin + L-glutamate	-	?

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Release 2023.1 (January 2023)