Literature summary for 3.4.19.13 extracted from

Grzam, A.; Martin, M.N.; Hell, R.; Meyer, A.J.
gamma-Glutamyl transpeptidase GGT4 initiates vacuolar degradation of glutathione S-conjugates in Arabidopsis (2007), FEBS Lett., 581, 3131-3138.

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Inhibitors

Inhibitors	Comment	Organism	Structure
acivicin	in cells treated with the xenobiotic monochlorobimane, application of acivicin leads to accumulation of glutathione S-bimane conjugates	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
vacuole	-	Arabidopsis thaliana	5773	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q9M0G0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione S-bimane + H2O	-	Arabidopsis thaliana	L-cysteinylglycyl S-bimane + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
At4g29210	locus name	Arabidopsis thaliana
GGT4	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
physiological function	enzyme calatyzes the first step in vacuolar degradation of glutathione conjugates. In Arabidopsis thaliana, degradation of glutathione S-conjugates strictly occurs by the ordered removal of Glu first and Gly second. Hydrolysis of glutathione S-bimane is blocked in enzyme null mutants	Arabidopsis thaliana

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Release 2023.1 (January 2023)