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Literature summary for 3.4.19.1 extracted from

  • Zhu, J.; Wang, Y.; Li, X.; Han, W.; Zhao, L.
    Understanding the interactions of different substrates with wild-type and mutant acylaminoacyl peptidase using molecular dynamics simulations (2018), J. Biomol. Struct. Dyn., 36, 4285-4302 .
    View publication on PubMed
Search for more literature for 3.4.19.1

Protein Variants

Protein Variants Comment Organism
R526V Ac-Leu-4-nitroanilide bound to R526V AAP to form a more disordered loop (residues 552-562) in the alpha/beta-hydrolase fold like of AAP, which causes an open and inactive AAP domain form, secondly, binding 4-nitrophenylcaprylate and Ac-Leu-4-nitroanilide to AAP can decrease the flexibility of residues 225-250, 260-270 and 425-450, in which the ordered secondary structures may contain the suitable geometrical structure and so it is useful to serine attack Homo sapiens

Organism

Organism UniProt Comment Textmining
Aeropyrum pernix Q9YBQ2
-
-
Aeropyrum pernix ATCC 700893 Q9YBQ2
-
-
Aeropyrum pernix DSM 11879 Q9YBQ2
-
-
Aeropyrum pernix JCM 9820 Q9YBQ2
-
-
Aeropyrum pernix NBRC 100138 Q9YBQ2
-
-
Homo sapiens P13798
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl caprylate + H2O
-
 Aeropyrum pernix 4-nitrophenol + caprylate
-
 ?
4-nitrophenyl caprylate + H2O
-
 Homo sapiens 4-nitrophenol + caprylate
-
 ?
4-nitrophenyl caprylate + H2O
-
 Aeropyrum pernix ATCC 700893 4-nitrophenol + caprylate
-
 ?
4-nitrophenyl caprylate + H2O
-
 Aeropyrum pernix DSM 11879 4-nitrophenol + caprylate
-
 ?
4-nitrophenyl caprylate + H2O
-
 Aeropyrum pernix JCM 9820 4-nitrophenol + caprylate
-
 ?
4-nitrophenyl caprylate + H2O
-
 Aeropyrum pernix NBRC 100138 4-nitrophenol + caprylate
-
 ?
N-acetyl-L-Leu-4-nitroanilide + H2O
-
 Aeropyrum pernix N-acetyl-L-Leu + 4-nitroaniline
-
 ?
N-acetyl-L-Leu-4-nitroanilide + H2O
-
 Homo sapiens N-acetyl-L-Leu + 4-nitroaniline
-
 ?
N-acetyl-L-Leu-4-nitroanilide + H2O
-
 Aeropyrum pernix ATCC 700893 N-acetyl-L-Leu + 4-nitroaniline
-
 ?
N-acetyl-L-Leu-4-nitroanilide + H2O
-
 Aeropyrum pernix DSM 11879 N-acetyl-L-Leu + 4-nitroaniline
-
 ?
N-acetyl-L-Leu-4-nitroanilide + H2O
-
 Aeropyrum pernix JCM 9820 N-acetyl-L-Leu + 4-nitroaniline
-
 ?
N-acetyl-L-Leu-4-nitroanilide + H2O
-
 Aeropyrum pernix NBRC 100138 N-acetyl-L-Leu + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
AAP
-
 Aeropyrum pernix
AAP
-
 Homo sapiens
acylaminoacyl peptidase
-
 Aeropyrum pernix
acylaminoacyl peptidase
-
 Homo sapiens
ApAAP
-
 Aeropyrum pernix

General Information

General Information Comment Organism
evolution enzyme AAP belongs to alpha/beta-hydrolase enzyme superfamily Aeropyrum pernix
evolution enzyme AAP belongs to alpha/beta-hydrolase enzyme superfamily Homo sapiens
additional information substrate binding structures of wild-type and mutant enzymes, docking study and molecular dynamics simulations, overview. Molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) calculations Aeropyrum pernix
additional information substrate binding structures of wild-type and mutant R526V enzymes, docking study and molecular dynamics simulations, overview. Molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) calculations Homo sapiens