Application | Comment | Organism |
---|---|---|
medicine | cathepsin X inhibitor causes neuroprotection via its inhibition of the activation of microglia. Cathepsin X can be a potential therapeutic target for neuroinflammatory disorders | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMS36 | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9WUU7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BV-2 cell | microglial cell | Mus musculus | - |
EOC-13.31 cell | microglial cell | Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
metabolism | there is a significant release of cathepsin X from activated BV2 and EOC 13.31 cells following a lipopolysaccharide stimulus that coincides with reduced release of the active form of gamma-enolase | Mus musculus |
physiological function | up-regulated expression and increased release and activity of microglial cathepsin X leads to microglia activation-mediated neurodegeneration | Mus musculus |