Literature summary for 3.4.18.1 extracted from

Pislar, A.H.; Zidar, N.; Kikelj, D.; Kos, J.
Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells (2014), Neuropharmacology, 82, 121-131.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PC-12 cell	-	Rattus norvegicus	-

General Information

General Information	Comment	Organism
physiological function	downregulation of cathepsin X expression by siRNA attenuates the neuronal death caused by 6-hydroxydopamine. Treatment with specific cathepsin X inhibitor AMS36 protects cells against 6-hydroxydopamine mediated cytotoxicity, resulting in reduced cell death and apoptosis.Inhibitor AMS36 reverses 6-hydroxydopamine-induced loss of tyrosine hydroxylase and attenuates 6-hydroxydopamine-induced activation of caspase-3. Cathepsin X may be responsible for dopamine neuron death, involved in the pathogenic cascade event for the neurodegenerative disorders, such as Parkinson's disease	Rattus norvegicus

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Release 2023.1 (January 2023)