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Literature summary for 3.4.18.1 extracted from

  • Naegler, D.K.; Kraus, S.; Feierler, J.; Mentele, R.; Lottspeich, F.; Jochum, M.; Faussner, A.
    A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists (2010), Int. Immunopharmacol., 10, 134-139.
    View publication on PubMed
Search for more literature for 3.4.18.1

Application

Application Comment Organism
diagnostics Cathepsin X is an inflammatory marker Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of the proenzyme in Pichia pastoris Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bradykinin + H2O Homo sapiens the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand ?
-
 ?
kallidin + H2O Homo sapiens the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification processing of the recombinant proenzyme by cathepsin L Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from Pichia pastoris by cation exchange chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, a mainly B2 receptor Homo sapiens Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg an exclusive B1 receptor ?
bradykinin + H2O the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand Homo sapiens ?
-
 ?
kallidin + H2O the peptide is converted from a bradykinin B2 receptor ligand to a bradykinin B1 receptor specific ligand Homo sapiens ?
-
 ?
kallidin + H2O i.e. Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, a mainly B2 receptor Homo sapiens Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe + Arg an exclusive B1 receptor ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function cathepsin X generates peptide receptor agonists and acts as a type I kininase. It is a cysteine-type carboxypeptidase and able to modulate the kallikrein–kinin system through carboxyterminal processing of the small peptide hormones bradykinin and kallidin. Cathepsin X as an alternative possible link between the kallikrein–kinin system and the renin–angiotensin system in that it not only cleaves kinins C-terminally, but also converts angiotensin I to angiotensin II, reaction of EC 3.6.15.1 Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.17
-
 bradykinin pH 5.5 Homo sapiens
5.75
-
 kallidin pH 5.5 Homo sapiens