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Literature summary for 3.4.18.1 extracted from

  • Kos, J.; Jevnikar, Z.; Obermajer, N.
    The role of cathepsin X in cell signaling (2009), Cell Adh. Migr., 3, 164-166.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.18.1

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
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 Homo sapiens 5764
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin X acts as a monocarboxypepidase and has a strict positional and narrower substrate specificity relative to the other human cathepsins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBR2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
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monocyte
-
 Homo sapiens
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additional information cathepsin X is a lysosomal cysteine protease, found predominantly in cells of monocyte/macrophage lineage Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin X acts as a monocarboxypepidase and has a strict positional and narrower substrate specificity relative to the other human cathepsins Homo sapiens ?
-
 ?

General Information

General Information Comment Organism
physiological function active cathepsin X enhances adhesion of monocytes/macrophages to fibrinogen and regulates the phagocytosis. By activation of Mac-1 receptor cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Cathepsin X activates also the other ?2 integrin receptor, LFA-1, which is involved in the proliferation of T lymphocytes. By modulating the activity of LFA-1 cathepsin X causes cytoskeletal rearrangements and morphological changes of T lymphocytes enhancing ameboid-like migration in 2-D and 3-D barriers and increasing homotypic aggregation. The cleavage of C-terminal amino acids of alpha and gamma enolase by cathepsin X abolishes their neurotrophic activity affecting neuronal cell survival and neuritogenesis. Role of cathepsin X in cell signaling, detailed overview Homo sapiens