Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.18.1 extracted from

  • Leichsenring, A.; Baecker, I.; Wendt, W.; Andriske, M.; Schmitz, B.; Stichel, C.C.; Luebbert, H.
    Differential expression of cathepsin S and X in the spinal cord of a rat neuropathic pain model (2008), BMC Neurosci., 9, 80.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.18.1

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
-
peroxisome
-
 Rattus norvegicus 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 proform of CATX, confirmed by Western blot analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CATX is an important player in the spinal mechanisms involved in chronic pain induction and maintenance ?
-
 ?
additional information Rattus norvegicus CATX is widely expressed in the brain and is implicated in several neurological conditions such as Alzheimer's disease, amyotrophic lateral sclerosis and age-related inflammation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male wistar rat
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-
spinal cord grey and white matter Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 at day 8 after 5th lumbar spinal nerve transection, CATX activity increases strongly and highly significant in the lumbar segment (59% compared to sham operated animals, 90% compared to naive) Rattus norvegicus
additional information
-
 expression and activity of CATX is upregulated in the spinal cord during the development and progression of neuropathic pain in the CNS of the rat 5th lumbar spinal nerve transection model after lesion, the strongest increase in protein content is found in the thoracic segment (87.4%) Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CATX is an important player in the spinal mechanisms involved in chronic pain induction and maintenance Rattus norvegicus ?
-
 ?
additional information CATX is widely expressed in the brain and is implicated in several neurological conditions such as Alzheimer's disease, amyotrophic lateral sclerosis and age-related inflammation Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin X
-
 Rattus norvegicus
CATX
-
 Rattus norvegicus