Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074 | - |
Homo sapiens | |
chicken cystatin | - |
Homo sapiens | |
cystatin C | - |
Homo sapiens | |
GFG-semicarbazone | - |
Homo sapiens | |
Stefin A | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
(2,4-dinitrophenyl)-GFFW | pH 5.1, 37°C | Homo sapiens | |
0.0018 | - |
(2,4-dinitrophenyl)-GFFGW | pH 5.1, 37°C | Homo sapiens | |
0.0024 | - |
(2,4-dinitrophenyl)-GFRFW | pH 5.1, 37°C | Homo sapiens | |
0.0036 | - |
(2,4-dinitrophenyl)-GFFRW | pH 5.1, 37°C | Homo sapiens | |
0.0037 | - |
ortho-aminobenzoyl-Phe-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro | pH 5.1, 37°C | Homo sapiens | |
0.0042 | - |
(2,4-dinitrophenyl)-GFRW | pH 5.1, 37°C | Homo sapiens | |
0.0046 | - |
(2,4-dinitrophenyl)-GRFFW | pH 5.1, 37°C | Homo sapiens | |
0.0083 | - |
ortho-aminobenzoyl-Arg-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + | pH 5.1, 37°C | Homo sapiens | |
0.0105 | - |
ortho-aminobenzoyl-Lys-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro | pH 5.1, 37°C | Homo sapiens | |
0.063 | - |
CBZ-FR-7-amido-4-methylcoumarin | pH 5.1, 37°C | Homo sapiens | |
0.13 | - |
CBZ-RR-7-amido-4-methylcoumarin | pH 5.1, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | mature cathepsin X has at least one of the two potential glycosylation sites glycosylated | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2,4-dinitrophenyl)-GFFGW + H2O | - |
Homo sapiens | (2,4-dinitrophenyl)-GFFG + L-Trp | - |
? | |
(2,4-dinitrophenyl)-GFFRW + H2O | - |
Homo sapiens | (2,4-dinitrophenyl)-GFFR + L-Trp | - |
? | |
(2,4-dinitrophenyl)-GFFW + H2O | - |
Homo sapiens | (2,4-dinitrophenyl)-GFF + L-Trp | - |
? | |
(2,4-dinitrophenyl)-GFRFW + H2O | - |
Homo sapiens | (2,4-dinitrophenyl)-GFR + L-Phe-L-Trp | - |
? | |
(2,4-dinitrophenyl)-GFRW + H2O | - |
Homo sapiens | (2,4-dinitrophenyl)-GFR + L-Trp | - |
? | |
(2,4-dinitrophenyl)-GRFFW + H2O | - |
Homo sapiens | (2,4-dinitrophenyl)-GRFF + L-Trp | - |
? | |
(2-aminobenzoyl)-FFF + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FF + L-Phe | - |
? | |
(2-aminobenzoyl)-FFFA + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFF + L-Ala | - |
? | |
(2-aminobenzoyl)-FFFP + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFF + Pro | - |
? | |
(2-aminobenzoyl)-FFFR + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFF + L-Arg | - |
? | |
(2-aminobenzoyl)-FFFR-NH2 + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFF + Arg-amide | - |
? | |
(2-aminobenzoyl)-FFFW + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFF + L-Trp | - |
? | |
(2-aminobenzoyl)-FFGW + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFG + L-Trp | - |
? | |
(2-aminobenzoyl)-FFRW + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFR + L-Trp | - |
? | |
(2-aminobenzoyl)-FFRW-NH2 + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FFR + L-Trp-amide | - |
? | |
(2-aminobenzoyl)-FRFW-NH2 + H2O | - |
Homo sapiens | (2-aminobenzoyl)-FR + Phe-Trp-amide | - |
? | |
2-aminobenzoyl-Arg-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-Leu-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + H2O | - |
Homo sapiens | ? | - |
? | |
2-aminobenzoyl-Phe-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + H2O | - |
Homo sapiens | ? | - |
? | |
3-aminobenzoyl-FR-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P + H2O | - |
Homo sapiens | 3-aminobenzoyl-FR + (2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P | - |
? | |
3-aminobenzoyl-LR-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P + H2O | - |
Homo sapiens | 3-aminobenzoyl-LR + (2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P | - |
? | |
3-aminobenzoyl-RR-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P + H2O | - |
Homo sapiens | 3-aminobenzoyl-RR + (2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P | - |
? | |
benzyloxycarbonyl-FR-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | benzyloxycarbonyl-FR + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-RR-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | benzyloxycarbonyl-RR + 7-amino-4-methylcoumarin | - |
? | |
additional information | the enzyme normally acts as a carboxymonopeptidase. The preference for Arg in the P1 position is so strong that cathepsin X cleaves substrates with Arg in antepenultimate position, acting also as a carboxypeptidase. A large hydrophobic residue such as Trp is preferred in the P1' position, although the enzyme cleaves all P1' residues investigated (Trp, Phe, Ala, Arg, Pro). The enzyme also cleaves the substrates with amide-blocked C-terminal carboxyl group with rates similar to that of the unblocked substrates | Homo sapiens | ? | - |
? | |
ortho-aminobenzoyl-Arg-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + H2O | - |
Homo sapiens | ? | - |
? | |
ortho-aminobenzoyl-Lys-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + H2O | - |
Homo sapiens | ? | - |
? | |
ortho-aminobenzoyl-Phe-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin Z | - |
Homo sapiens |
cysteine-type carboxypeptidase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
(2,4-dinitrophenyl)-GFFGW | pH 5.1, 37°C | Homo sapiens | |
0.02 | - |
2-aminobenzoyl-Leu-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + | pH 5.1, 37°C | Homo sapiens | |
0.03 | - |
(2,4-dinitrophenyl)-GFRFW | pH 5.1, 37°C | Homo sapiens | |
0.06 | - |
2-aminobenzoyl-Arg-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + | pH 5.1, 37°C | Homo sapiens | |
0.07 | - |
(2,4-dinitrophenyl)-GFFW | pH 5.1, 37°C | Homo sapiens | |
0.07 | - |
2-aminobenzoyl-Phe-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + | pH 5.1, 37°C | Homo sapiens | |
0.22 | - |
benzyloxycarbony-FR-4-methylcoumaryl-7-amide | pH 5.1, 37°C | Homo sapiens | |
0.23 | - |
(2,4-dinitrophenyl)-GRFFW | pH 5.1, 37°C | Homo sapiens | |
0.3 | - |
(2,4-dinitrophenyl)-GFFRW | pH 5.1, 37°C | Homo sapiens | |
0.63 | - |
benzyloxycarbony-RR-4-methylcoumaryl-7-amide | pH 5.1, 37°C | Homo sapiens | |
0.7 | - |
(2,4-dinitrophenyl)-GFRW | pH 5.1, 37°C | Homo sapiens | |
6.08 | - |
benzyloxycarbony-RR-4-methylcoumaryl-7-amide | pH 5.1, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
reaction with 3-aminobenzoyl-FR-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P | Homo sapiens |
5 | 5.5 | reaction with benzyloxycarbonyl-RR-4-methylcoumaryl-7-amide | Homo sapiens |
5 | 6 | reaction with (2,4-dinitrophenyl)-GFFW | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
3.5 | 5.5 | pH 3.5: about 50% of maximal activity, pH 5.5: about 50% of maximal activity, reaction with 3-aminobenzoyl-FR-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-P | Homo sapiens |
4 | 6.5 | pH 4.0: about 45% of maximal activity, reaction with benzyloxycarbonyl-RR-methylcoumarinamide | Homo sapiens |
4.5 | 6.5 | pH 4.5: about 45% of maximal activity, pH 6.5: about 10% of maximal activity, reaction with (2,4-dinitrophenyl)-GFFW | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000017 | - |
Stefin A | pH 5.5, 25°C | Homo sapiens | |
0.000012 | - |
cystatin C | pH 5.5, 25°C | Homo sapiens | |
0.000015 | - |
chicken cystatin | pH 5.5, 25°C | Homo sapiens | |
0.0166 | - |
GFG-semicarbazone | pH 5.5, 25°C | Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | isoelectric focusing | - |
5.1 |