Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thrombin-thrombomodulin complex | on the vascular endothelial surface | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-2-mercaptomethyl-3 guanidinoethylthiopropanoic acid | specific inhibitor for CPN but not CPB | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0143 | - |
fibrinopeptide-beta-Lys125-133 | - |
Homo sapiens | |
0.034 | - |
fibrinopeptide-gamma-Lys54-62 | - |
Homo sapiens | |
0.035 | - |
C3a69-77 | peptide derived from bradykinin | Homo sapiens | |
0.0359 | - |
C3a69-77 | - |
Homo sapiens | |
0.0532 | - |
fibrinopeptide betaLys125-133 | - |
Homo sapiens | |
0.0706 | - |
bradykinin | - |
Homo sapiens | |
0.077 | - |
C3a69-77 | peptide derived from bradykinin | Homo sapiens | |
0.1228 | - |
chemerin | - |
Homo sapiens | |
0.143 | - |
fibrinopeptide betaLys125-133 | - |
Homo sapiens | |
0.17 | - |
chemerin | - |
Homo sapiens | |
0.219 | - |
C5a66-74 | peptide derived from bradykinin | Homo sapiens | |
0.238 | - |
fibrinopeptide gammaLys77-85 | - |
Homo sapiens | |
0.2389 | - |
fibrinopeptide-gamma-Lys77-85 | - |
Homo sapiens | |
0.302 | - |
bradykinin | - |
Homo sapiens | |
0.34 | - |
fibrinopeptide gammaLys54-62 | - |
Homo sapiens | |
0.361 | - |
fibrinopeptide alphaArg96-104 | - |
Homo sapiens | |
0.3614 | - |
fibrinopeptide-alpha-Arg96-104 | - |
Homo sapiens | |
0.448 | - |
fibrinopeptide alphaArg96-104 | - |
Homo sapiens | |
0.602 | - |
C5a66-74 | peptide derived from bradykinin | Homo sapiens | |
0.657 | - |
fibrinopeptide gammaLys54-62 | - |
Homo sapiens | |
0.706 | - |
bradykinin | - |
Homo sapiens | |
3.727 | - |
fibrinopeptide gammaLys77-85 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P15169 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
blood platelet | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
C3a69-77 + H2O | - |
Homo sapiens | ? | - |
? | |
C3a69-77 + H2O | peptide derived from bradykinin | Homo sapiens | ? | - |
? | |
C5a66-74 + H2O | - |
Homo sapiens | ? | - |
? | |
C5a66-74 + H2O | peptide derived from bradykinin | Homo sapiens | ? | - |
? | |
chemerin + H2O | - |
Homo sapiens | ? | - |
? | |
chemerin + H2O | CPB enhances the bioactivity of 10-mer chemerin peptide NH2-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine | Homo sapiens | ? | - |
? | |
chemerin + H2O | CPN enhances the bioactivity of 10-mer chemerin peptide NH2-YFPGQFAFSK-COOH by removing the carboxyl-terminal lysine | Homo sapiens | ? | - |
? | |
fibrinopeptide alphaArg96-104 + H2O | - |
Homo sapiens | ? | - |
? | |
fibrinopeptide betaLys125-133 + H2O | - |
Homo sapiens | ? | - |
? | |
fibrinopeptide gammaLys54-62 + H2O | - |
Homo sapiens | ? | - |
? | |
fibrinopeptide gammaLys77-85 + H2O | - |
Homo sapiens | ? | - |
? | |
fibrinopeptide-alpha-Arg96-104 + H2O | - |
Homo sapiens | ? | - |
? | |
fibrinopeptide-beta-Lys125-133 + H2O | - |
Homo sapiens | ? | - |
? | |
fibrinopeptide-gamma-Lys54-62 + H2O | - |
Homo sapiens | ? | - |
? | |
fibrinopeptide-gamma-Lys77-85 + H2O | - |
Homo sapiens | ? | - |
? | |
prochemerin + H2O | sequential cleavages of either a prochemerin peptide or recombinant full-length prochemerin by plasmin and CPN/CPB substantially increases their chemotactic activities | Homo sapiens | ? | - |
? | |
prochemerin + H2O | sequential cleavages of either a prochemerin peptide or recombinant full-length prochemerin by plasmin and CPN/CPB substantially increases their chemotactic activities. Endogenous CPN present in circulating plasma enhances the activity of plasmin-cleaved prochemerin | Homo sapiens | ? | - |
? | |
YFPGQFAFSK + H2O | bioacivity of 10-mer chemerin peptide, chemerin 149-158, is enhanced by removing the carboxyl-terminal lysine | Homo sapiens | YFPGQFAFS + lysine | - |
? | |
YFPGQFAFSKALPRS + H2O | sequential cleavage of prochemerin peptide, chemerin 149-163, by CPB increases chemotactic activities | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activated thrombin-activable fibrinolysis inhibitor | - |
Homo sapiens |
carboxypeptidase B | - |
Homo sapiens |
carboxypeptidase N | - |
Homo sapiens |
CPB | - |
Homo sapiens |
CPN | - |
Homo sapiens |
plasma carboxypeptidase | - |
Homo sapiens |
TAFIa | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
activity assay | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.5 | - |
fibrinopeptide alphaArg96-104 | - |
Homo sapiens | |
1.5 | - |
fibrinopeptide-alpha-Arg96-104 | - |
Homo sapiens | |
2.6 | - |
fibrinopeptide gammaLys54-62 | - |
Homo sapiens | |
2.6 | - |
fibrinopeptide-gamma-Lys54-62 | - |
Homo sapiens | |
2.7 | - |
chemerin | - |
Homo sapiens | |
2.9 | - |
fibrinopeptide alphaArg96-104 | - |
Homo sapiens | |
3.5 | - |
fibrinopeptide gammaLys54-62 | - |
Homo sapiens | |
5.9 | - |
fibrinopeptide gammaLys77-85 | - |
Homo sapiens | |
5.9 | - |
fibrinopeptide-gamma-Lys77-85 | - |
Homo sapiens | |
8.4 | - |
C3a69-77 | - |
Homo sapiens | |
8.4 | - |
C3a69-77 | peptide derived from bradykinin | Homo sapiens | |
9.1 | - |
bradykinin | - |
Homo sapiens | |
9.3 | - |
C5a66-74 | peptide derived from bradykinin | Homo sapiens | |
11.8 | - |
fibrinopeptide gammaLys77-85 | - |
Homo sapiens | |
13.6 | - |
fibrinopeptide betaLys125-133 | - |
Homo sapiens | |
13.6 | - |
fibrinopeptide-beta-Lys125-133 | - |
Homo sapiens | |
19.7 | - |
bradykinin | - |
Homo sapiens | |
29.5 | - |
C5a66-74 | peptide derived from bradykinin | Homo sapiens | |
57.9 | - |
C3a69-77 | peptide derived from bradykinin | Homo sapiens | |
80.35 | - |
chemerin | - |
Homo sapiens | |
109.1 | - |
fibrinopeptide betaLys125-133 | - |
Homo sapiens |