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Literature summary for 3.4.17.23 extracted from

  • Ahmad, I.; Pawara, R.; Surana, S.; Patel, H.
    The Repurposed ACE2 Inhibitors SARS-CoV-2 entry blockers of covid-19 (2021), Top. Curr. Chem., 379, 40 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
6-gingerol inhibition of the ACE2 enzyme Homo sapiens
amentoflvaone inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
andrographolide inhibition of the ACE2 enzyme Homo sapiens
apigenin inhibition of the ACE2 enzyme Homo sapiens
arbidol inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
artemisnin inhibition of the ACE2 enzyme Homo sapiens
asparoside C inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
AY-NH2 inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
Berberine inhibition of the ACE2 enzyme Homo sapiens
beta-sitosterol inhibition of the ACE2 enzyme Homo sapiens
bis-demethoxy curcumin inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
cepharanthine potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
chebulagic acid inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
crisimaritin inhibition of the ACE2 enzyme Homo sapiens
cucurbitacin B inhibition of the ACE2 enzyme Homo sapiens
curcumin inhibition of the ACE2 enzyme Homo sapiens
cynaropicrin inhibition of the ACE2 enzyme Homo sapiens
darunavir inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
denopamine inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
dithymoquinone inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
ergoloid potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
eriodictyol potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
favipiravir potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
hesperidin inhibition of the ACE2 enzyme; inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
hispudulin inhibition of the ACE2 enzyme Homo sapiens
hydroxychloroquine potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
hypericin potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
isoniazid pyruvate potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
isothymol inhibition of the ACE2 enzyme Homo sapiens
ivermectin inhibition of the ACE2 enzyme; potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
menthol potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
MLN-4760 inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
additional information inhibitors of SARS-CoV-2:ACE2 binding Homo sapiens
naringin inhibition of the ACE2 enzyme Homo sapiens
neoandrographolide inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
Nitrofurantoin potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
orientin inhibition of the ACE2 enzyme Homo sapiens
paritaprevir inhibition of the ACE2 enzyme Homo sapiens
piceatannol inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
pseudojervine inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
quercetin inhibition of the ACE2 enzyme Homo sapiens
quercetin-3-O-galatosyl-rhamnosyl-glucoside inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
raspberry ketone potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
rutin inhibition of the ACE2 enzyme Homo sapiens
rutin DAB10 inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
saikosaponin A inhibition of the ACE2 enzyme Homo sapiens
spinochrome A inhibitor of SARS-CoV-2-(receptor binding domain):ACE2 complex Homo sapiens
thymoquinone potential inhibitor of the SARS-CoV-2-S protein:ACE2 complex Homo sapiens
vitexin inhibition of the ACE2 enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oral mucosa
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function SARS-CoV-2 binds to the angiotensin converting enzyme 2 (ACE2) receptor of the host cells through the viral surface spike glycoprotein (S-protein). ACE2 is expressed in the oral mucosa and can therefore constitute an essential route for entry of SARS-CoV-2 into hosts through the tongue and lung epithelial cells Homo sapiens