Literature summary for 3.4.17.23 extracted from

Li, F.; Li, W.; Farzan, M.; Harrison, S.C.
Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005), Science, 309, 1864-1868 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of a complex of soluble angiotensin-converting enzyme 2 (ACE2), residues 19 to 615 and SARS-CoV spike protein receptor binding domain (RBD), residues 306 to 575. Crystals in space group P21, a = 82.3 A, b = 119.4 A, c = 113.2 A, beta = 91.2°, with two complexes per asymmetric unit, are grown at room temperature from a mother liquor containing 24% polyethylene glycol 6000, 150 mM NaCl, 100 mM Tris at pH 8.2, and 10% ethylene glycol. The crystal structure at 2.9 A resolution of the RBD of the SARS-CoV spike protein bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase	Homo sapiens

Crystallization (Comment)

Organism

crystal structure of a complex of soluble angiotensin-converting enzyme 2 (ACE2), residues 19 to 615 and SARS-CoV spike protein receptor binding domain (RBD), residues 306 to 575. Crystals in space group P21, a = 82.3 A, b = 119.4 A, c = 113.2 A, beta = 91.2°, with two complexes per asymmetric unit, are grown at room temperature from a mother liquor containing 24% polyethylene glycol 6000, 150 mM NaCl, 100 mM Tris at pH 8.2, and 10% ethylene glycol. The crystal structure at 2.9 A resolution of the RBD of the SARS-CoV spike protein bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase

Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BYF1	-	-

Purification (Commentary)

Purification (Comment)	Organism
soluble ACE2, residues 19 to 615, was expressed in Sf9 cells	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
ACE2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the angiotensin-converting enzyme-2 is the receptor for the SARS-coronavirus (SARS-CoV). The spike protein of SARS-CoV attaches the virus to its cellular receptor, angiotensin-converting enzyme 2. A defined receptor binding domain on the spike protein mediates this interaction	Homo sapiens

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Release 2023.1 (January 2023)