BRENDA - Enzyme Database
show all sequences of 3.4.17.23

Angiotensin-converting enzyme 2 in the brain: properties and future directions

Xia, H.; Lazartigues, E.; J. Neurochem. 107, 1482-1494 (2008)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
development of a transgenic mouse model (syn-hACE2) where the full open reading frame of the human ACE2 gene is under the control of a synapsin promoter, allowing the hACE2 protein to be expressed specifically in neurons
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Zn2+
metallopeptidase
Homo sapiens
Zn2+
metallopeptidase
Mus musculus
Zn2+
metallopeptidase
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
angiotensin II + H2O
Homo sapiens
the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin
angiotensin-(1-7) + Phe
-
-
?
additional information
Homo sapiens
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited
?
-
-
-
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
Q9BYF1
-
-
Mus musculus
Q8R0I0
-
-
Rattus norvegicus
Q5EGZ1
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
brain
ACE2 is widespread throughout the brain, present in nuclei involved in the central regulation of cardiovascular function like the cardio-respiratory neurons of the brainstem, as well as in non-cardiovascular areas such as the motor cortex and raphe
Homo sapiens
-
brain
predominantly in neurons
Mus musculus
-
kidney
in salt-sensitive Sabra hypertensive (SBH/y) rats, ACE2 mRNA and protein expression are lower than that in salt-resistant Sabra normotensive (SBN/y) rats
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
angiotensin I + H2O
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited
693733
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
?
angiotensin II + H2O
-
693733
Mus musculus
angiotensin-(1-7) + Phe
-
-
-
?
angiotensin II + H2O
-
693733
Rattus norvegicus
angiotensin-(1-7) + Phe
-
-
-
?
angiotensin II + H2O
the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin
693733
Homo sapiens
angiotensin-(1-7) + Phe
-
-
-
?
angiotensin II + H2O
ACE2 has approximately a 400fold greater affinity for Ang-II than Ang-I
693733
Homo sapiens
angiotensin-(1-7) + Phe
-
-
-
?
additional information
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited
693733
Homo sapiens
?
-
-
-
-
additional information
hydrolyses its substrates by removing a single amino acid from their respective C-terminal
693733
Homo sapiens
?
-
-
-
-
Synonyms
Synonyms
Commentary
Organism
ACE 2
-
Homo sapiens
ACE 2
-
Mus musculus
ACE 2
-
Rattus norvegicus
Ang converting enzyme 2
-
Homo sapiens
Ang converting enzyme 2
-
Mus musculus
Ang converting enzyme 2
-
Rattus norvegicus
angiotensin converting enzyme 2
-
Mus musculus
angiotensin converting enzyme 2
-
Rattus norvegicus
angiotensin converting enzyme 2
-
Homo sapiens
hACE2
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
development of a transgenic mouse model (syn-hACE2) where the full open reading frame of the human ACE2 gene is under the control of a synapsin promoter, allowing the hACE2 protein to be expressed specifically in neurons
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Zn2+
metallopeptidase
Homo sapiens
Zn2+
metallopeptidase
Mus musculus
Zn2+
metallopeptidase
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
angiotensin II + H2O
Homo sapiens
the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin
angiotensin-(1-7) + Phe
-
-
?
additional information
Homo sapiens
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
brain
ACE2 is widespread throughout the brain, present in nuclei involved in the central regulation of cardiovascular function like the cardio-respiratory neurons of the brainstem, as well as in non-cardiovascular areas such as the motor cortex and raphe
Homo sapiens
-
brain
predominantly in neurons
Mus musculus
-
kidney
in salt-sensitive Sabra hypertensive (SBH/y) rats, ACE2 mRNA and protein expression are lower than that in salt-resistant Sabra normotensive (SBN/y) rats
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
angiotensin I + H2O
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited
693733
Homo sapiens
angiotensin-(1-9) + Leu
-
-
-
?
angiotensin II + H2O
-
693733
Mus musculus
angiotensin-(1-7) + Phe
-
-
-
?
angiotensin II + H2O
-
693733
Rattus norvegicus
angiotensin-(1-7) + Phe
-
-
-
?
angiotensin II + H2O
the major role of ACE2 in Ang peptides metabolism is the production of Ang-(1-7). ACE2 also participates in the metabolism of other peptides non related to the renin-angiotensin system: apelin-13, neurotensin, kinetensin, dynorphin, [des-Arg9]-bradykinin, and [Lys-des-Arg9]-bradykinin
693733
Homo sapiens
angiotensin-(1-7) + Phe
-
-
-
?
angiotensin II + H2O
ACE2 has approximately a 400fold greater affinity for Ang-II than Ang-I
693733
Homo sapiens
angiotensin-(1-7) + Phe
-
-
-
?
additional information
the affinity for Ang-I is poor in comparison with ACE, therefore the conversion of Ang-I to Ang-(1-9) is not of physiological importance, except maybe under conditions in which ACE activity is inhibited
693733
Homo sapiens
?
-
-
-
-
additional information
hydrolyses its substrates by removing a single amino acid from their respective C-terminal
693733
Homo sapiens
?
-
-
-
-
Other publictions for EC 3.4.17.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)