Literature summary for 3.4.17.23 extracted from

Rella, M.; Rushworth, C.A.; Guy, J.L.; Turner, A.J.; Langer, T.; Jackson, R.M.
Structure-based pharmacophore design and virtual screening for novel angiotensin converting enzyme 2 inhibitors (2006), J. Chem. Inf. Model., 46, 708-716.

Search for more literature for 3.4.17.23

Inhibitors

Inhibitors	Comment	Organism	Structure
1N-08795	90% inhibition at 0.2 mM	Homo sapiens
1N-26923	93% inhibition at 0.2 mM	Homo sapiens
1N-27714	89% inhibition at 0.2 mM	Homo sapiens
1N-28616	93% inhibition at 0.2 mM	Homo sapiens
1S-90995	11% inhibition at 0.2 mM	Homo sapiens
1S-91206	75% inhibition at 0.2 mM	Homo sapiens
3S-95223	40% inhibition at 0.2 mM	Homo sapiens
4S-14713	70% inhibition at 0.2 mM	Homo sapiens
4S-16659	76% inhibition at 0.2 mM	Homo sapiens
5115980	1% inhibition at 0.2 mM	Homo sapiens
7490938	20% inhibition at 0.2 mM	Homo sapiens
7850455	20% inhibition at 0.2 mM	Homo sapiens
7857351	27% inhibition at 0.2 mM	Homo sapiens
7870029	11% inhibition at 0.2 mM	Homo sapiens
additional information	not inhibited by rentiapril, ceranopril, indolaprilat, zofenoprilat, spiraprilat, quinaprilat, perindoprilat, fosinoprilat, cilazaprilat, captopril, lisinopril, and enalaprilat	Homo sapiens
T0507-4963	41% inhibition at 0.2 mM	Homo sapiens
T0513-5544	4% inhibition at 0.2 mM	Homo sapiens
T0515-3007	13% inhibition at 0.2 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(7-methoxycoumarin-4-yl)acetyl-APK(2,4-dinitrophenyl) + H2O	-	Homo sapiens	(7-methoxycoumarin-4-yl)acetyl-AP + N6-(2,4-dinitrophenyl)-L-lysine	-	?
angiotensin II + H2O	-	Homo sapiens	angiotensin-(1-7) + Phe	-	?

Synonyms

Synonyms	Comment	Organism
ACE2	-	Homo sapiens
angiotensin converting enzyme 2	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.062	-	-	Homo sapiens	4S-16659
0.08	4	-	Homo sapiens	1S-91206
0.096	-	-	Homo sapiens	1N-08795
0.116	-	-	Homo sapiens	1N-28616
0.134	-	-	Homo sapiens	1N-26923
0.179	-	-	Homo sapiens	4S-14713

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Release 2023.1 (January 2023)