Application | Comment | Organism |
---|---|---|
medicine | recombinant ACE2 can protect mice from severe acute lung injury | Mus musculus |
Organism | UniProt | Comment | Textmining |
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Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | ACE2 and the AT2 receptor protect against lung injury. Exogenous recombinant human ACE2 attenuates acute lung failure in Ace knockout as well as in wild-type mice. Acute lung injury results in a marked downregulation of ACE2. Loss of ACE2 expression in acute lung injury leads to leaky pulmonary blood vessels through AT1 receptor stimulation | Mus musculus | - |