Literature summary for 3.4.17.22 extracted from

Singh, U.; Yu, Y.; Kalinina, E.; Konno, T.; Sun, T.; Ohta, H.; Wakayama, T.; Soares, M.J.; Hemberger, M.; Fundele, R.H.
Carboxypeptidase E in the mouse placenta (2006), Differentiation, 74, 648-660.

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Application

Application	Comment	Organism
medicine	CPE, probably in combination with CPD, has a functional role in normal placental development, specifically in control of giant cell and glycogen cell growth. In addition, Cpe together with Cpd is an upstream determinant of interspecies hybrid placental dysplasia, whose lack produces placental phenotypes reminiscent of interspecies hybrid placental dysplasia. Pathways regulated by these enzymes are not only important in placentation, but potentially also for speciation in the genus Mus	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O89001	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	Cpd and CPE are strictly co-localized in the mouse placenta from late mid-gestation to term. While there is no strict overlap between Cpe and Cpd transcripts at the early developmental stages, E8 and E10, from E12 onwards there is no obvious difference in the expression patterns of the two genes. Just like Cpe, Cpd is expressed primarily in decidua and in chorionic plate and yolk sac, with weak expression in the labyrinth. At E18, Cpd is expressed at a level higher than Cpe. In interspecies hybrid placental dysplasia placentas, the expression of Cpd overlapps with that of Cpe. There is no difference in the pattern of expression of Cpd in wild-type and fat placentas at E18. Strong expression in decidua and yolk sac, but weak and diffuse expression in the labyrinth	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Carboxypeptidase D	-	Mus musculus
CPD	-	Mus musculus

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Release 2023.1 (January 2023)