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Literature summary for 3.4.17.21 extracted from
- Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities (2016), FEBS J., 283, 2528-2545 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| X-ray structure of the inactive enzyme with the engineered mutation E424A in complex with beta-citrylglutamate, hanging drop vapour diffusion method | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E424A | inactive mutant enzyme | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no modulation of activity by divalent cations | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q04609 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no cleavage of beta-citrylglutamate | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GCPII | - |
Homo sapiens |
| glutamate carboxypeptidase II | - |
Homo sapiens |
| Prostate-specific membrane antigen | - |
Homo sapiens |
| PSMA | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the enzyme is involved in neurological disorders and overexpressed in a number of solid cancers | Homo sapiens |
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Release 2023.1 (January 2023)
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